Expression And Its Clinical Significance Of LAT1CD98and KI-67in Colon Cancer

Objective:To study the expression and clinical significance of L-Type Amino Acid Transporte-r-1(LAT1)、 CD98and KI-67in colon cancer and elucidate the relationship between their overexpression and clinical pathological characteristics.Methods:The human mucosa of80patients with colon cancer and20healthy persons were followed up between2012and2013at Second Affiliated Hospital, Shan xi Medical University, the expression of LAT1、CD98and KI-67were detected by using immunohistochemistry.Results:Immunohistochemistry showed that the positive rate of LAT1accounted for65.0%(39/60) in colon cancer,and20%(4/20) in healthy persons tissues(P<0.001). The positive expression rates of CD98was66.7%in colon cancer and15%in healthy persons tissues(P<0.001), The positive expression rates of LAT1was63.3%in colon cancer,and15%in healthy persons tissues(P<0.001). The expression of LAT1, CD98and KI-67in poorly differentiated colon cancer stage Ⅲ-Ⅳ IV were significantly higher than in well differentiated colon cancer, stage I-II (P<0.05). In colon cancer with lymph metastasis their expression were significantly higher than that in colon cancer without lymph metastasis (P<0.05). The expression of LAT1and CD98were relevant to the tumor size and the expression of KI-67was no relevant to the tumor size. The higher expression of LAT1, CD98hc and KI67in colon cancer were with a positive correlation among them (P<0.05).Conclusion:Over expression and relevant of LAT1、 CD98and KI-67were present in colon cancer. The expression of LAT1、 CD98and KI-67were relevant to the pathology、 Clinical stage and lymph matastasis. They may serve as the fairly good prognostic Factors to indicate biologic behavior and the possibility of new therapy in colon cancer.