Application Fundamental Research On The Preparation Of Acanthopanax Senticosus Harms Prescription

The modernization of preparation of Chinese material medica is an important part in the studies of the modernization of traditional Chinese medicine. It must identify the natural connection between material basis and pharmacodynamic action to provide scientific evidences for optimization of pharmaceutical technology; Biopharmaceutical foundation research of TCM provides scientific evidences for dosage form design of it.1. To optimize purification technology binding pharmacodynamics. Optimization of purification technology of Acanthopanax senticosus Harms binding pharmacodynamics for identify the natural connection between therapeutic material basis and pharmacodynamic action of anti-cerebral ischemia, and provides scientific evidence for optimization of pharmaceutical technology. It applies modern technologies to refine eleutherosides, and optimize technical parameters. As a result, the contents of eleutheroside B is positive correlation to pharmacodynamic action of anti-cerebral ischemia.2. Carried out the studies on physiological disposition and dosage form design. To compare pharmacodynamic action of anti-cerebral ischemia of different dministration route, it found that it’s not intragastric administration but intraperitoneal injection of Acanthopanax senticosus Harms can enhance the capability of anti-cerebral ischemia highly significant. It also found that the poor oral administration bioavailability by pharmacokinetics study. To aim directly at good dissolubility of eleutheroside B, we study permeability and stability during the transport process to explain the poor oral administration bioavailability. In study of permeability using in situ perfusion model in rat, we found that eleutheroside B has better permeability in duodenum, jejunum and ileum. In study of stability, we found that eleutheroside B can keep it’s stability in artificial gastric juice and intestine perfusate, but it can be degraded rapidly by enteric enzyme. All of above are response to the poor oral administration bioavailability of eleutheroside B.3. In the forming technology study of freeze-dry powder injection, guided by the indexes of surface characters and ELU B content, it has been surveyed which included the selection the technological parameters of the variety, concentration and dosage of bracket excipient, concentration of confecting liquid, and freeze-dry technology.