Synthetic Amino Derivatives, Gelling Properties And Application

Since supramolecular gels possess their own unique self-assembly capability, as well as in awide range of potential applications, in recent years more and more people are concerned. Thesynthesis of pyridine derivatives paper Gelators and studied in detail in the water solvent gellingability, self-assembled morphology and molecular arrangement, and further use of the gel as atemplate to produce an amino derivative of the polymer film, used in drug delivery, access to someof the promising results, the main conclusions are as follows:(1) Design and Synthesis of the monomeric material while there is a carboxyl group, apyridyl group and an amide group in the unit molecule DAP molecules, it is a good potentialhydrogel factor, the experiments show that when the concentration is greater than or equal to43mg/mL when DAP can form a stable gels, when the temperature was raised to81o C stable gelgel collapses precipitate formed when the pH is alkaline, DAP can not form a hydrogel, and DAPis not formed with urea, acetic acid, etc. bicomponent hydrogel. It with water to a plurality ofsynergy between the molecules to form a stable hydrogel is a disordered fiber network of themulti-crystalline microstructure, forming the self-assembly of the main driving force of thehydrogel is intermolecular hydrogen bonding.(2) Since N-hexadecyl adipamide (C16) in toluene to form stable organic gels, with a longerstabilization period, so that the gel structure does not collapse in a long deformation; the gel Gel-sol transition temperature is high to ensure that the high temperatures during the molding processof the gel polymerization stage will be affected; the gel by a three-dimensional network structuremicron fibers interwoven the mold to provide the desired micron pore the conditions.The N-hexadecyl adipamide in toluene as a template to form an organic gel, successfullyproduced the organic polymer film micron pore size. The polymeric membrane with a variety ofunique excellent properties, decided that it is an excellent drug carrier.(3)Because the N-palmitoyl hexamethylene diamine (C16)toluene organic gel as a templatemade of organic micron pore polymeric film stability is strong and has the function to control thedrug release rate, is very suitable as a drug carrier for drug delivery research. This experimentsalicylate Alternative Medicine, and the organic polymeric film in the water of the salicylic acidsustained release. At a room temperature of25℃, the salicylic acid (SA) under the sameconditions of quality and volume of MBA change quality when of N-Palmitoyloxyphenylhexamethylenediamine (C16), the organic polymeric film in the water release rate of the salicylicacid no effect. Quality and MBA N-palmitoyl hexamethylenediamine (C16) at a room temperatureof25℃, constant volume, the organic polymeric film release rate of salicylic acid in water isgradually reduced with the increase in the mass of salicylic acid. At a room temperature of25℃, the mass of N-palmitoyl hexamethylenediamine (C16), MBA volume and constant quality of thesalicylic acid, the organic polymeric film faster release rate of salicylic acid in the acidic aqueoussolution, followed by the release rate in an aqueous alkaline solution is slow, but the pH value ofthe aqueous solution has little influence on the final release rate.