Clinical Observation Of Primary Nephrotic Syndrome (Yin Deficiency Syndrome) Shenqidihuang Decoction Combined Hormone Therapy

Objective:To observe the effect of Shenqi Dihuang Decoction Combined with hormone in the treatment of primary nephrotic syndrome (PNS)(syndrome of deficiency of Qi and Yin two) clinical efficacy, and explore its possible mechanisms of action.Methods:Randomized control study, with60patients were randomly divided into control group (standard with glucocorticoid is the main drug) and observation group (the control group on the basis of Shenqi Dihuang Decoction), a total of8weeks of treatment. Selection of clinical symptoms, TCM24hour urinary protein, plasma albumin, serum creatinine, blood glucose, triglyceride, total cholesterol, blood pressure as the observation items, were observed after treatment. The obtained data accord with normal distribution, using t test and X2test were used for statistical analysis; data does not conform to normal distribution, nonparametric tests were used for statistical analysis.Results:(1) The total effect of the two groups:the total effective rate of observation group was86.6%,60%in the control group, the observation group than in the control group, the P<0.05, there were significant differences;(2) compared two groups of TCM syndrome curative effect:the observation group was86.6%,66.7%in the control group, the observation group than in the control group, P<0.05, there was significant difference (3); Comparison of TCM syndrome integral:observation group was20.20±2.27, control group was11.27±2.21, P<0.05, there are significant differences;(4) after treatment, TCM syndrome integral,24hUP, TC, TG was lower than that in control group, while ALB was higher than that of the control, P<0.05, there are significant differences;(5) the clinical treatment had no obvious adverse reaction.Conclusion:Shenqi Dihuang Decoction Combined with hormone in the treatment of PNS (Qi and yin deficiency syndrome in patients with two) than the simple use of hormone therapy, mechanism of Shenqi Dihuang decoction may be related to the immunomodulatory, anti-inflammatory, worthy of further study.