Phlegm Drink Spleen Qi Deficiency Clinical Overweight And Simple Obesity Treatment

Objective:In the early stage of the study about Syndromes of overweight and obesity which based on the questionnaire data analysis and summary, combining with professor Xu Yuan’s clinical practice of the treatment using buqixiaotanyin to treat the patient who was overweight and obese in the type of the deficiency of spleen and kidney. Put the patients into two groups randomly and controlled study was adopted and undertook clinical observation.Objective to observe the clinical effect of buqixiaotanyin in the treatment of overweight and obesity. In order to provide evidence for clinical practice by assessing the effectiveness and safety of buqixiaotanyin for the syndrome of overweight and obesity.Methods:Cases with overweight and obese in the type of the deficiency of spleen and kidney were divided into the trial group and the contrast group by random number table method(each31cases). Four weeks before entering the study subjects, which began to control diet and exercise regularly, and does not take any drugs which affect weight. Drugs to control blood glucose and blood pressure continue to be used in the original program. The trial group use buqixiaotanyin, fasting and before dinner each time, once a bag(200milliliter) and the contrast group only control diet and exercise regularly. The two groups were treated60days. The general information on two groups of patients, respectively, from gender, age, course of the disease, weight, body mass index, waistline, Waist-hip ratio, blood lipid levels, multiaspect comparison and analysis of the pre-treatment baseline, there were no significant statistical differences. The clinical symptom integral table was formulated according to dialectical classification and clinical characteristics of obesity in Chinese traditional medicine new drug clinical research guiding principle, TCM diagnosis and the quantization diagnose of TCM. Meanwhile, the change of fasting blood glucose, blood lipid level and adiponeetin were monitored. Blood routine examination, liver and function, electrocardiogram were monitored. According to the treatment of comprehensive curative effect, the change of TCM symptom score, each measurement such as weight, blood lipid levels and adiponeetin in therapeutic process, evaluating the curative effect and prognosis of buqixiaotany in treatment of overweight and obese in the type of the deficiency of spleen and kidney, meanwhile, analysising the change of various indexes. To observe its recurrence rate and evaluate adverse reactions and side effects about buqixiaotanyin during treatment after3months follow up.Results:60days after treatment:1. Comparison and analysis of the comprehensive curative effect:The effective rate of the trial group was67.74%,and the effective rate of the contrast group was6.45%.The difference of two groups was marked(P<0.01).2.Efficacy of TCM Syndrome Analysis:The total effective rate of the treatment of TCM was70.97%and12.90%.The difference of two groups was marked(P<0.01),and the TCM treatment of the trial group was significantly higher efficiency.3.Weight,body mass index and waistline:The weight, body mass index and waistline of the trial group have improved much more significantly during treatment, and the difference was marked(P<0.01).There has been an evident difference between the the trial group and the contrast group(P<0.01), which indicates that there is a certain advantage in changing weight, body mass index and waistline between the trial group and the contrast group.4.Blood lipid level:The level of TG、 TC and LDL-C of all cases in the trial group were depressed obviously and the level of HDL-C of all cases in the trial group were increasing to a certain degree after treatment.5. The level of adiponectin (APN):Following the treatment, there has been an obvious growth trend than that in pre-treatment in the trial group and the difference was significant among two groups (P<0.01).6. All patients of two groups were examined in the general blood tests (including liver and kidney functional tests and EKG and sternum)or urine and fecal examinations before and after treatment. And there was no significant difference after2months of treatment in the process. In the course of treatment, there was no significant adverse reactions among patients of both groups.Conclusion:1. In reducing weight, improving clinical symptoms improving patient’s blood lipid levels and adiponectin levels, Buqixiaotanyin had good curative effect.2. The safety of buqixiaotanyin was satisfactory.3. The compliance and tolerance of buqixiaotanyin appeared quite well. The clinical trial results showed that buqixiaotanyin could obviously improve clinical symptoms of patients who were overweight and obese in the type of the deficiency of spleen and kidney, worthy of clinical popularization and more widespread clinical use, and further exploration of its therapeutic mechanism.