| Objective:The purpose of this study is to observe and evaluate Dibei gargle Prescription in the treatment to minor recurrent oral ulcer.Method:ROU patients chosen from clinic of Wangjing Hospital of China Academy of Chinese Traditional Medicine were selected between June2013and February2014.The ROU cases were randomly divided into a treatment group of33cases and a control group of33cases.The treatment group used Dibei gargle Prescription, and the control group used compound chlorhexidine collutory. The use methods is:20ml pur use, gargle in the mouth for about2minutes, two times daily, the total observational course was3days. The observational indexes consist of:the diameter of ulcer, the number of ulcer, and the pain index. Then the results of the indexes were observed and recorded after3-days treatment.Application SPSS19.0software for analysis.Results:1. Analysis on the baseline condition of the two groupsThere is no statistical significance between the two groups after the general conditions of the two groups of patients like gender, age, illness process, as well as the local symptoms including the number, diameter, and degree of pains of the ulcers were examined statistically, but comparability exists between the two groups.2. Analysis on the treatment effectsAfter the two groups were treated respectively, the scores evaluating the syndrome of traditional Chinese medicine were improved. According to the evaluation on the treating effects on syndrome of traditional Chinese medicine, the overall effective efficiency of the experimental group is93.9%while that of the matched group is78.8%plus that the contrast differences between the two groups are of statistical significance; after the two groups were treated, the overall effective rate of the experimental group for the partial treating effect of the ulcer is96.7%, while that for the matched group is81.8%and the contrast differences between the two groups are of statistical significance.3. Symptoms of local ulcerThe diameter of the ulcer is improved after being treated. The average values of the ulcer of the patients within the experimental group on the baseline and after being treated are (3.09±0.91)mm and (0.67±1.08)mm respectively, and the comparison between the former one and the latter is of statistical significance. The average values of the ulcer of the patients within the matched group on the baseline and after being treated are (2.93±0.86)mm and (1.52±1.18)mm respectively, and the comparison between the former one and the latter is of statistical significance. The relief has been relieved after being treated. The average values of the former and latter pain indexes within the experimental group are (7.09±1.59)mm and (1.27±1.91)mm respectively, and the comparison between the former one and the latter is of statistical significance. The average values of the former and latter pain indexes within the matched group are (7.03±1.49)mm and (3.09±2.78)mm respectively, and the comparison between the former one and the latter is of statistical significance. The experimental group and the matched group were compared after being treated and the distinctions are of statistical significance. Ulcer hyperemia and edema scores have been both improved after treatment, and the comparison between the former treatment and the latter one is of statistical significance. There is statistical significance between the experimental group and the matched group after treatment.4. Comparison of the average ulcer periodThe average values of the average ulcer periods of the experimental group before and after treatment are (8.64±2.23) days and (6.67±2.35) days respectively, and the distinction between the statuses before and after the treatment is of statistical significance. The average values of the average ulcer periods of the matched group before and after the treatment are (8.06±1.84) days and (7.52±1.66) days respectively, and the distinction between the statuses before and after the treatment is of statistical significance. In addition, the distinctions between the changes of average ulcer periods of the two groups after the treatment are of statistical significance.Conclusion:Both the Dibei gargle Prescription and the Compound Chlorhexidine Giuconatie Gargle Solution could effectively relieve the local symptoms of recurrent oral ulceration (ROU), reduce the pain caused by ulcer and shorten the average ulcer period. Compared to the Compound Chlorhexidine Giuconatie Gargle Solution, the Dibei gargle Prescription could better improve the local symptoms of the patients, reduce the ulcer edema, promote healing, and relieve pains. |
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