| Primary sjogren’s syndrome is considered to be a autoimmune disease, which always affect the exocrine gland especially the salivary gland and the tear gland. The majority symptoms are dry mouth and dry eyes or even the injury of multiple systems and organs. There are a mount of lymphocytes infiltrating in the tissue involved and characterized by the multiple antibody positive in the serum. The syndrome also called autoimmune exocrine gland disease, Gougerot-Houwe syndrome or Sjogren’s diseasesyndrome. The pathogenesis and pathogeny are unknown to the western medicine, so there are less methods with strong target and effectiveness. The results of external applications for local syndromes are not satisfied. Although there are some internal treatments, which are also good for the local syndrome, such as immune inhibitors or hormone, have lots of side effects.Professor Lu Zhi-zheng have more than70years experience in clinical medicine and has accumulated rich clinical experience especially for the Bi syndrome. He firstly put up "Dry Bi" as a disease name of TCM and bring the sjogren’s syndrome into the category of the Dry Bi. Though the connotation of the Dry Bi in TCM is much larger than the SS, there are some enlightenment in exploring the Dry Bi in TCM which is advantageous to the treatment.The research inherits and develops the academic though from professor Lu Zhi-zheng in treating the SS. According to the clinical observation for the patients who are considered in Dry Bi, treat with Runzao decoction, to evaluate the curative effect and safeness. Our research originate from "The TCM treatment and effective evaluation of sjogren’s syndrome based on the experience of professor Lu Zhi-zheng", the research is designed by open experiment, itself before and after comparison which involved65patients who are considered in the standard of Dry Bi. The research will last three mouths and we will observe the laboratory examination and the test index, VAS evaluation of the dry mouth and the grade on fatigue both in the research and after the research to evaluate the curative effect and safeness about the Runzao decoction for SS patients in deficiency of qi and yin. Here is the result:1. The Runzao decoction can release the syndrome of dry mouth in a short time for patients with PSS in deficiency of qi and yin. And it can increase the lacrymal gland’s secretion of pSS.2. The IgG which is used to reflect the disease activity can be improved, but the level of ESR, RF, SSA, SSB, ANA are relatively steady.3. The manifestation of TCM in three month treating by Runzao decoction shows that the effective percentage of releasing the syndrome of dry mouth is about95.31%.4. The effective percentage of TCM syndrome is90.77%after three month treating by Runzao decoction.5. The safeness of Runzao decoction in treating PSS patients in deficiency of qi and yin is convincing in the short time treating.Conclusively, by comparison the result in the first, second, third mouth,before and after research about TCM syndrome, clinical symptoms, serum laboratory index and the sign of life, to evaluate the effectiveness and safeness about Runzao decoction in treating PSS patient in deficiency of qi and yin. The result shows that the Runzao decoction can release the clinical symptoms and some of the laboratory index in a short time with highly safeness. So it can be extended. |
PDF Full Text Request