Different Concentrations Of Remifentanil And Propofol In Children With Cerebral Palsy After Selective Dorsal Rhizotomy Anesthesia In Comparison

1ObjectiveTo assess the effect of four different target-controlled reminfentanil infusion in combination with target-controlled propofolinfusion(TCI)on hemodynamic stability and recovery characteristics in children undergoing selective posterior rhizotomy(SPR) in children.2Methods80ASA physical status1and2children, aged3-14years, presenting for selective dorsal rhizotomy. Children were divided randomly into four groups(20cases in each group) to receive either a target concentration of2ng/ml (Group1) or3ng/ml (Group2) or4ng/ml (Group3) or5ng/ml(Group4) of remifentanil infusion. Anesthesia was induced and maintained with remifentanil combined with propofol TCI.Propofol effect compartment concentration was maintained at4ug/ml. Heart rate, mean arterial pressure, BIS value,the nerve stimulation threshold induced dorsal contraction, the awareness and other adverse reactions were recorded before and after the nerve root elective stimulus in children.3resultsThere were significant differences in both Group1and Group2with respect to MAP and HR before and after the nerve root elective stimulus(P<0.01). No significant differences were found in MAP and HR in group3and group4before and after the nerve root elective stimulus(P>0.05).4ConclusionsEffect site concentration of remifentanil ranging4or5ng/ml in combination with propofol TCL was associated with satifactory anesthesia effects during selective posterior rhizotomy(SPR) in children.