Study On The Reaction Of Organometallic Reagents Mediated Bylewis Acid And Aldehydes

Organometallic reagents are very important nucleophilic reagent in organic synthesis. They are widely used in medicine, industry, agriculture as well as in photoelectric materials and ceramic areas.This thesis first summarizes some common reactions that several mostly used organometalic compounds such as organo-magnesium compounds, organic zinc compounds, organo-lithium compounds, organoaluminium compounds, organic copper aluminum, indium reagents, organic titanium compounds participated. They share some similarities in some reactions, such as with the nucleophilic addition reaction of carbonyl compound, coupling reaction, and the cyclic compound reaction, alkylation reaction, rearrangement reaction etc.Our research focused on the Lewis acid mediated organometallic reagents and aldehydes This reaction was believed to proceeded first Grignard reagent was modified by alkyl alkoxyzinc reagent to give a mixed organometallic reagent which enable the alkoxyl group nucleophilic attack the carbonyl group of substrate aldehyde to afford a hemiacetal anion, then an organic group migrate from zinc to substitute the hydride anion to generate the ketone. We explore the reaction conditions and the optimal reaction condition was found to be: Grignard reagents: alkyl alkoxy zinc reagent: aldehyde: proton accept agent = 2:1:1:2. All the synthesized compounds are identified and characterized by IR, 1H NMR, 13 C NMR, GC-MS.