Study On Synthesis Technology Of Fluorinated Pyridine Fine Chemicals

Because of its pseudo-blocking effect, a high negative charge and hydrophobicity and other characteristics of a fluorine atom, a lot of the fluorine-containing medicines and pesticides in the performance has to use less, low toxicity, high efficacy, metabolic ability and other characteristics, so that in the field of new pharmaceutical and pesticide widely used.This topic was supported by the Guizhou Wylton Jinlin Electronic Materials Co. Ltd. entrusted, synthesis of 15 through market research selected fluoride-pyridine class fine chemicals, complete the synthesis process research or optimization, lay the foundation for future research in test.Method fluorinated pyridine compounds include diazo method, electrochemical fluorination method, fluorine substitution reaction, fluoro denitration method, a halogen exchange fluorination, NF electrophilic fluorinating reagent fluorination method, etc. Integrated the advantages and disadvantages of various methods fluoride, this subject adopts the fluoboric acid heavy nitrogen and hydrogen fluoride fluoride pyridine nitrogen transform amino for fluoride fluorine atoms.This topic is taken some simple pyridine compounds and organic reagents as raw material, by introducing some specific groups, eventually in the pyridine ring the specific location of the introduction of fluorine atoms, get a fluoride pyridine class fine intermediate products. The main focus is to get through the synthetic route pyridine fluorine fine chemicals, a comprehensive review of the relevant literature and experimental progress, select the appropriate method, solvents, reagents, reaction temperature, reaction time and other production processes to optimize or improve, the product was purified and its molecular structure by MS and 1HNMR characterization, the title compound is confirmed by the purity and structure.