Preparation And Adsorption Properties Of Quinolone Imprinted Polymer

In recent years molecular imprinting technique (MIT) is more important with a new technology in the specific selectivity and affinity of molecular recognition materials, with unique advantages of predetermination, recognition and practicability, showing excellent prospects for development in the field of medicine, food and environmental. Ciprofloxacin is a quinolone antibiotic, and is widely used in clinical due to its antimicrobial spectrum, strong sterilization effect, rapid onset of action. In recent years, excessive use of ciprofloxacin cause residues in the environment, which pose a threat to human health. Thus ciprofloxacin residue analysis has become one of the issues most concern.Molecular imprinted polymer was prepared by suspension polymerization method, which using ciprofloxacin as template molecule, methyl acrylic acid as functional monomer, and methyl acrylate as crosslinking agent. SEM and FT-IR were used to characterize the molecular imprinted polymer. Different ratio between template molecule and crosslinking agent, and different ratio between template molecule and functional monomer had been investigated in details and the optimal proportion of the composite was established. The effect of solution pH, temperature for the adsorption of polymer had been investigated in details. The adsorption mode of the polymer was determined for many factors, which was proved according to Langmuir, Frundlich and Scatchard equation. The selective adsorption between ciprofloxacin and levofloxacin indicated that the polymer had a specific adsorption of ciprofloxacin. The adsorption amount of the polymer still reached 92.3% of initial after the three times which indicated good stability.The spherical Fe3O4 nanoparticles were synthesized by solvothermal method. The Fe3O4 nanoparticles was coated with SiO2 to the surface with hydroxyl groups, then subjected to the silylation reaction, and finally magnetic molecularly imprinted polymer was polymerized. The effect of solution pH, temperature for the adsorption of polymer had been investigated in details and the optimum adsorption conditions were established. According to adsorption isotherm and Langmuir, Frundlich and Scatchard equation, the adsorption mode of the polymer was determined for many factors, which proved the synthesis of molecular imprinting. The selective adsorption between ciprofloxacin and levofloxacin indicated that the polymer had a specific adsorption of ciprofloxacin. The adsorption effect of the polymer can reach 86.3% of initial after the three times which indicated good stability.Molecular imprinted polymer was prepared by suspension polymerization method, which using ofloxacin and enrofloxacin as template molecule, methyl acrylic acid as functional monomer, and methyl acrylate as crosslinking agent. SEM and FT-IR were used to characterize the molecular imprinted polymer which indicated that molecularly imprinted polymers synthesized successfully. Different ratio between template molecule and crosslinking agent, and different ratio between template molecule and functional monomer had been investigated in details and the optimal proportion of the composite was established. According to adsorption isotherm and Langmuir, Frundlich and Scatchard equation, the adsorption mode of the polymer was determined for many factors, which proved the synthesis of molecular imprinting. Solid adsorption experiment indicated that the imprinted polymer can be used as adsorbent for the adsorption of different quinolones.