Study About Clinical Features And Influence Factor Of Prognosis For Bone Metastasis Of Breast Cancer

Objective: Through case viewing, sum up the clinical and pathological features of bonemetastasis from breast cancer patients cured in our hospital in recent10years, to discussregulation and parts distribution of bone metastasis from breast cancer; interviewing thepatients, investigating their living condition to discuss negative factors of bone metastasisfrom breast and to provide theoretical reference to clinical treatment and prognosisestimation.Method: To select patients that are diagnosed bone metastasis from breastcancer in General Hospital of Ningxia Medical University from Jan.2002to Jan.2011asresearch objective, Via calling, re-examination and interviewing the patients to sum up andanalysis parts distribution and clinical pathological features of bone metastasis from breastcancer. Sorting the cases which are surgical treated but not suffer radiation or chemo, definingmain line as the period time between surgical treatment to bone metastasis, usingKaplan-Meier to analysis the relationship between bone metastasis time and clinicalpathological features of breast cancer, as well as the living condition of the patients, usingsingle and multiple statistical methods to analyze the negative factors of bone metastasis frombreast cancer. Result: Totally150cases bone metastasis occur mainly in multiple focuses,metastasis parts in sequences are spine, chest, pelvis, limbs and skull. Metastasis rate is75.3%,74.0%,56.0%,46.7%and28.7%separately, there is statistical significant betweendifferent metastasis parts (P<0.01). Regarding these150patients,135patients were surgicaltreated, metastasis-free time is from1to255months, median time is28months. Metastasisrate within1year,3years and5years is separately23.0%(31/135),59.30%（80/135) and74.80%（101/135). Single factor of Kaplan-Meier shows that onset age, pathological type, tumor size, lymph node metastasis quantity, the stage and chemo will impact metastasis-freetime (P<0.05), The age, menstrual status, lymph node metastasis quantity, stage, endocrinetreatment, ALP level, combination of visceral metastasis, CerbB-2and parts of bonemetastasis are general factors of bone metastasis from breast cancer. Using multiple causesCox regression to analyze these factors, which shows that onset age, pathological type, lymphnode metastasis quantity and chemo are independent factors factors of metastasis-free time ofbread cancer, endocrine treatment, lymph node metastasis quantity, combination of visceralmetastasis, CerbB-2and parts of bone metastasis are independent factors of prognosis.Conclusions:1.Bone metastasis from breast cancer is prone to the aged, mainly focusamong40to50. Metastasis rate reaches maximum3years after surgical treatment. Parts ofmetastasis in subsequence are spine, chest, pelvis, limbs and skull.2.Onset age, lymph nodemetastasis quantity, pathological type of breast cancer and chemo are independent prognosisfactors of metastasis-free time for bread cancer patient.3.Lymph node metastasis quantity,endocrine treatment, combination of visceral metastasis and CerbB-2initial single/multiplemetastasis are independent prognosis factors of surviving rate of bone metastasis from breadcancer patients.4.The lever of CA15-3in peripheral blood is higher than100U/ml and serumalkaline phosphatase may be the poor prognostic factors of bone metastasis from breadcancer.But the lever of CEA can not be used as indicators to determine bone metastasis frombread cancer.