Study On The Relationships Of The Oral Manifestations And Cd4+T Lymphocyte Count And The Level Of TH1/TH2Subsets In HIV/AIDS Patients Undergoing Haart

Objective:To observe the relationship of the oral health status, CD4+T lymphocyte count and the level of Th1/Th2subsets in HIV/AIDS patients undergoing HAART, and to investigate the HAART’s effects to HIV/AIDS patients’ oral health status, local and systemic immunization.Materials and methods:A total of23HIV/AIDS patients diagnosed by Guangxi Center for Disease Control and Prevention were included in this study, and all of them were at baseline (CD4+T lymphocyte count <350cells/mm3), oral examination was carried out, clinic data was recorded,and peripheral blood was collected to detect the CD4+T lymphocyte count and the percentage of the Th1/Th2subsets using flow cytometry. The HIV/AIDS patients undergoing HAART were required for further consultation at3th month and6th month.23age and gender matched healthy individuals were included as health controlsf baseline.Results:1.14of23HIV/AIDS patients at baseline showeded oral manifestation, including5patients with oral candidiosis,6oral hairy leukoplakia,2oral ulcer,2oral leukoplakia.3patients were founde combined oral manifestations. Oral candidiosis showeded the fastest response to HAART, except two cases, all of them had disappeared when they received HAART for3months, while oral hairy leukoplakia was slower to HAART.During the first3months,4cases’scope could grow down partly,but all of them still existed at6months after HAART2. The CD4+T lymphocyte count of HIV/AIDS patients at baseline and healthy donors were212.17±130.24cells/mm3and757.48±232.50cells/mm3, the former was significantly lower than the latter(P<0.001), and the percentage of the Thl subsets in healthy donors and HIV/AIDS patients at baseline were4.68±0.54%and0.77±0.29%, the former was significantly higher than the latter(P<0.001); while the percentage of the Th2subsets in healthy donors and HIV/AIDS patients at baseline were1.64±0.23%and4.54±0.54%, the latter was higher than the former significantly(P<0.001).3. The CD4+T lymphocyte count in HIV/AIDS patients at baseline and undergoing HAART3and6months were212.17±130.24cells/mm3,300.35±149.85cells/mm3and308.52±159.21cells/mm3, repeated measures ANOVA showeded that there was statistical significance among the three groups, and LSD-t test showeded that there was statistical significance between the data at baseline and undergoing HAART3or6months,but there was no statistical significance between the data undergoing HAART3and6months.4. The percentage of the Thl subsets in HIV/AIDS patients at baseline and undergoing HAART3and6months were0.77±0.29%,1.17±0.43%and1.55±0.46%respectively, repeated measures ANOVA showeded that there was statistical significance among the three groups, and LSD-t test showedwd statistical significance between each two groups at baseline and undergoing HAART3and6months(P<0.001).5. The percentage of the Th2subsets in HIV/AIDS patients at baseline and undergoing HAART3and6months were4.54±0.54%,4.09±0.85%and3.19±0.69%. Repeated measures ANOVA showeded that there was statistical significance among the three groups, and LSD-t test showeded that there was statistical significance between each two groups at baseline and undergoing HAART3and6months (P<0.001).6. The CD4+T lymphocyte count and the percentage of the Th1subsets in HIV/AIDS patients had positive correlation relationship with HAART stage(P<0.05), while the percentage of Th2subsets had negative correlation relationship with HAART stage(P<0.001).Conclusions:1. HIV/AIDS patients have low level of the CD4+T lymphocyte count and Th1/Th2balance shift with Th2gaining advantage. They usually have oral manifestation, among which oral candidiosis and oral hairy leukoplakia are the most common.2. CD4+T lymphocyte count increased and Th1/Th2balance recovered partly among the HIV/AIDS patients during HAART, it suggested that the immunity reconstructed to certain degree. As to oral manisfestaion, HAART showeded different clinic effects on HIV-related oral lesions. Oral candidiosis had fast response to HAART, although oral hairy leukoplakia are slower. While oral ulcer and herpes simplex angular cheilitis can appear repeatedly during HAART stage.