Influencing Factors Of Poor Immune Reconstitution And Correlation Analysis Of Treg Cells,IL-10 And Immune Reconstitution In HIV/AIDS Patients

Objective To retrospective analysis the related factors of HIV/AIDS patients who were treated with highly active antiretroviral therapy(HAART)for more than 4 years and had achieved virology suppression but had poor immune reprogramming(PIR),and to explore the CD4~+CD25~+Foxp3~+T cells(Treg cells)and interleukin 10(IL-10)in patients with HIV/AIDS HAART clinical significance of the treatment process.Methods The HIV/AIDS patients were diagnosed on January 1,2020and December 31,2015by Huaihua First People’s Hospital and selected to meet the virology inhibition criteria after 4 years(48 months)of follow the baseline antiviral regimen treatment who were divided into two groups:the PIR group and Optimal immune responders(OIR)group.PIR baseline factors were retrospectively analyzed,including age,gender,baseline HCV/TB infection status,baseline CD4~+T lymphocyte count absolutely,Initial HAART treatment whether containing protease inhibitors PIs,CD4~+T cell growth at 1 year of treatment.In addition,Treg cells and IL-10 levels were measured at the time of inclusion in both groups.with a single variable(T test and chi-square test,etc.)and multivariate Logistic regression statistical methods,compared to the clinical data of two groups of patients,and the ROC curve was established to evaluate the degree of influence.Results There was significant difference in the factors of affecting immune reconstitution include age,baseline CD4~+T lymphocyte count,initial HAART treatment regimen,the increase of CD4~+T lymphocytes after 1 year(12 months)of treatment(P<0.01).while there was no significant difference in the combination of HCV infection and tuberculosis infection between the two groups(P≥0.05).ROC curves were established for different immune remodelling effects and baseline CD4~+T lymphocytes,suggesting a baseline CD4~+T lymphocyte threshold of 89 cells/u L.Comparison of the results of Treg cells between the two groups indicated a significant difference(P<0.05),but the comparison of IL-10 levels between the two groups indicated no significant difference(P>0.05).Conclusion1.Age,low baseline CD4~+T cell level(<89 cells/u L),CD4+T lymphocyte increase<100 cells/u L at 1 year of treatment,and whether the treatment regimens do not contains PIs are risk factors affecting the immune reconstructive function in HIV/AIDS patients during HAART.2.There may be a certain correlation between poor immune reconstitution of HIV/AIDS and Treg cells,but may be no significant correlation with IL-10 levels.