| AIM: To evaluate the effect of CYP2C9and VKORC1polymorphisms on the initialresponse to warfarin in local atrial fibrillation(af) patientsMethods: Warfarin therapy was taken in200local atrial fibrillation patients afteratril fibrillation radiofrequency ablation (RFCA),whose INR target value is between2.0to3.0. Patients were divided ramdomly into two groups, the gene group andcontrol group (non-gene group). Initial dose was given as the lowest one of gene testrecommendation dose in gene group. Warfarin dose was given in traditional way incontrol group.The time and average daily dose reaching target value were recorded inboth groupsResults: The time to the first target value was shorter in gene group than in controlgroup (8.92±2.09vs11.91±2.18,P<0.05). Average daily dose to the first target valuewas increased in patients carring VKORC1-1639A/G or G/G than VKORC1-1639A/A.（4.74±0.88vs3.42±0.60,P<0.05）. Average daily dose of INR first reachingtarget value in gene group was similar with gene recommendation scope.Conclusions: CYP2C9and VKORC1polymorphism test could help time to reachtarget value shortened, help warfarin average daily dose recommended. It is to someextent clinical significant to recommend the individualized warfarin dosage in theanti-coagulation paroxysmal atrial fibrillation after surgery. |
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