B-cell Lymphoma/Leukemia-2(Bcl-2)、 Cyclooxygenase-2(COX-2) And Neoadjuvant Chemotherapy In Cervical Cancer

ObjectiveTo evaluate the efficacy of neoadjuvant chemotherapy(NACT) for cervical cancerin the recent clinical; To investigate the expression of Bcl-2and COX-2in cervicalcancer before and after neoadjuvant chemotherapy and explore the feasibility ofpredicting the efficacy of neoadjuvant chemotherapy of detecting the expression ofBcl-2and COX-2.Materials and MethodsFrom January2011and December2011,22patients with cervical cancer werediagnosed The Fist People’s Hospital in Guangzhou. The patients were in line with theneoadjuvant chemotherapy(NACT) indications, and underwent neoadjuvantchemotherapy using cisplatin-based regiments in the center of the interventionaltreatment of department of gynaecology. The criteria of evaluating the NACT curativeeffect is the Response Evaluation Criteria In Solid Tumors(RECIST). Immunohistochemical SP method was used to detect the expression of Bcl-2andCOX-2before and after NACT. SPSS13.0statistical software was used for statisticalanalysis on all date. P <0.05has statistically significant.Results1. After neoadjuvant chemotherapy about14days,22cervical cancer patients wasevaluated the curative effect by gynecological examination, B-ultrasonic wave or MR.The complete regression(CR) accounted for9.09%(2/22), partial regression (PR)accounted for63.64%(14/22), disease progression (PD) accounted for4.55%(1/22),stable diseases (SD) accounted for22.72%(5/22). Total effective rate (CR+PR) was72.73%(16/20), inefficient rate (PD+SD) was27.27%(6/20).2. The expression of Bcl-2and COX-2of cervical cancer patients who hadneoadjuvant chemotherapy (NACT), before and after, had great differences. Thedifference had statistical significance (P <0.05); The expression of Bcl-2and COX-2were significantly lower after neoadjuvant chemotherapy in clinically effective (CR+PR), there is no statistical significance in clinically non-effective (PD+SD).3. The expression of Bcl-2and COX-2has no statistical significance (P>0.05) indifferent therapeutic groups before neoadjuvant chemotherapy.Conclusion1. The clinical effect of transarterial infusion chemo-embolization as a way ofNACT in cervical cancer patients is obvious. The recent curative effect is good.Patients endured less adverse reaction and well tolerated. The way of transarterialinfusion chemo-embolization is safe and reliable.2. The expression of Bcl-2and COX-2of cervical cancer patients who hadneoadjuvant chemotherapy (NACT), before and after, had great differences. Thedifference had statistical significance (P <0.05). It showed that cervical cancer tissueapoptosis increased and proliferation activity was significantly suppressed afterneoadjuvant chemotherapy. The malignant degree of cervical cancer tissue declined.3. The expression of Bcl-2and COX-2were significantly lower after neoadjuvant chemotherapy in clinically effective (CR+PR), there is no statisticalsignificance in clinically non-effective (PD+SD). It showed that the expression ofBcl-2and COX-2not only reflect the state of cervical cancer cell proliferation, butalso has certain clinical significance of evaluating the effect of neoadjuvantchemotherapy in cervical cancer patients. It will be more accurate that Bcl-2andCOX-2as markers is applied to determine the clinical curative effect.