The Correlation Research Of Inflammation And Lung Function Among Children With Asthma In Remission

Objective:understanding the lung function of children in remission stage of bronchialasthma, and exploring its relationship with airway inflammation indicators and levelsof inflammatory mediators to further provide clinical basis for the management andtreatment of children in remission stage of asthma.Methods:selected children in remission stage of asthma in79cases of children at theasthma clinic aged4to15years old from September2011to March2014in dalianchildren’s hospital with retrospective study. Patients with acute attack of asthma,congenital respiratory diseases, acuted respiratory infections history or lung infection,poor compliance which could not complete the examination were excluded.Pulmonary function, fractional exhaled nitric oxide (FeNO) and leukotrienes (LTs)levels were detected for those children in remission stage of asthma who met theinclusion criteria. Patients were divided into normal lung function, small airwaydysfunction and abnormal lung function group according to the results of pulmonaryfunction tests. The relationship among lung function and inflammatory indicatorswere analyzed.Results:1.In79cases of children in remission stage of asthma,49cases (62%) were withnormal lung function;17(21.5%) with small airway dysfunction;13(16.5%) withabnormal lung function, in which12were with mild pulmonary dysfunction,1withmoderate pulmonary dysfunction, accounting for15.2%and1.3%of children in remission stage of asthma respectively.2. In79cases of children in remission stage of asthma,50cases (63.3) were withnormal FeNO;29(36.7%) with increased FeNO. The difference of the two detectionof remission stage of asthma, lung function and FeNO, was significant and withstatistical significance. The correlation among FeNO and lung function indicatorsshowed that, MMEF and FeNO were correlated negatively and the correlationcoefficient was-0.261, while there was no correlation among other indicators andFeNO.3. In79cases of children in remission stage of asthma,33cases (41.8%) werewith normal LTs;46(58.2%) with abnormal LTs. The difference of the comparisonbetween the two detection of remission stage of asthma, lung function and LTs, wassignificant and with statistical significance. The correlation among LTs and lungfunction indicators showed that, MMEF had no correlation with LTs, while otherindicators were correlated to LTs negatively.4. In49children in remission stage of asthma with normal lung function,27cases were with normal LTs,22were abnormal. The abnormal rate was44.9%; therewere36case with normal FeNO,13were abnormal. The abnormal rate was26.5%.The difference of abnormal rate between LTs and FeNO was not significant. LTs hadno correlation with FeNO.Conclusion:1. Lung function, FeNO and LTs play important roles in the evaluation of remissionstage of asthma with different angles.The lung function of2/5of children in remissionstage of asthma remain abnormal,the airway inflammation of2/3of children inremission stage of asthma are not been fully controlled after asthma has beencontrolled，and about3/5of children in inflammation remain abnormal.2. FeNO is not correlated with lung function, LTs is a little correlated with lungfunction and two inflammations is not correlated with each other.These threedetection methods in evaluating remission stage of asthma are irreplaceable.