| Background:Recently, cystatin C has been proposed as a more early reliablemarker in diagnosis of renal function and prognosis，which has gradually beenrecognized by the industry. It is encoded by the housekeeping gene CST3type, andconsists of all nucleated cells produce a constant rate. Under the premise of normal renalfunction, cystatin C is as potentially dangerous cardiovascular disease markers hasattracted attention of professionals, especially small study of coronary heart diseaseprediction may be complementary with other indicators has also been reported.CystatinC may be complementary with other indicators on which is caused by hardening of thecoronary risk prediction of cardiovascular disease.And acute coronary syndrome hasbecome one of the serious cardiovascular events coronary atherosclerotic heart diseasehigher risk of death.Fragile unstable coronary plaque and coronary thrombosis can leadto blocking.Obejective:The clinical research study for acute coronary syndrome cystatinC,explore the relationship between in vivo acute coronary syndrome and cystatin Clevels in patients with coronary artery lesions. And cystatin C changes between differentsubgroups of acute coronary syndrome, explore the clinical significance of cystatin Cforeshadowed for acute coronary syndrome, to assist clinicians in the prevention,diagnosis and treatment of these cardiovascular diseases.Methods: Clinical data:1.Continuously collected from January2012to October2013at the People’sHospital of Liaoning Province circulation department with chest pain and acutecoronary syndrome and coronary angiography in patients stay.Record into the group ofpatients with general clinical situations: including age and sex, smoking and drinkinghistory, previous hypertension, cerebrovascular diseases, digestive diseases (such asulcers, acute gastritis, cirrhosis and cancer, etc.), metabolic diseases (such as thyroiddysfunction, adrenal disease, diabetes, etc.), rheumatic autoimmune diseases,hematopoietic system diseases (such as leukemia, thrombocytopenic purpura, etc.) andcancer and other serious chronic diseases.2.Patients admitted to hospital within24hours of blood, myocardial enzyme series(cardiac enzymes and troponin T), atrial natriuretic peptide, uric acid, cholesterol, liverfunction, kidney function (blood urea nitrogen and creatinine), urine routine and so theybiochemical tests,For selected patients before coronary angiography performed cystatinC testing.All biochemical parameters by Liaoning Provincial People’s Hospital testing.3.Coronary angiography: Select multi-position, different projection anglescoronary angiography, left coronary artery using a left anterior oblique+foot position,left anterior oblique+head position, head position right anterior oblique+/footposition angles angiography; right coronary artery using head position, left anterioroblique or right anterior oblique contrast different angles,Liaoning Provincial People’sHospital, the doctor involved in the cycle of high qualification Division readingangiographic results, and internationally accepted method of assessing coronaryangiography situation.CHD must meet coronary luminal diameter stenosis greater thanor equal to50%. According to the number of coronary lesions can be divided into single,double and three.Grouping method:1.126patients in the control group, mean age55.76±9.90years;experimental group were660cases, mean age55.88±10.06years old.2.First, begrouped according to the type of acute coronary syndrome, including357cases ofunstable angina, with an average age of55.98±10.00years;187cases of acute ST-segment elevation myocardial infarction;116cases of acute non-ST segmentelevation myocardial infarction.3.Unstable angina group divided according to thenumber of coronary lesions:128cases of single vessel disease;107cases ofdouble-vessel disease;122cases of three lesions.4.Acute myocardial infarctionaccording to the number of coronary lesions can be divided into:84patients withsingle-vessel disease,74cases of double-vessel disease,145cases of three lesions.Statistical analysis:Statistical Analysis SPSSl8.0statistical software, mean±standard deviation measurement data expressed in the form of data, using T-testbetween the two groups, analysis of variance among groups.Applying the percentage ofsaid count data, using the chi-square test methods were compared. Correlation analysisusing linear correlation and Spearman rank correlation test was used. Statisticallysignificant with P <0.05as measured by the standard.Results:1.Unstable angina group compared with the control group, thedifference was significantly (P <0.05); acute myocardial infarction group and thecontrol group equally cystatin C levels was significantly higher (P <0.05); UA groupand AMI cystatin C content group differences remained significant (P <0.05).2.Unstableangina group of single, double, triple vessel disease cystatin C levels were comparedwith the control group there was a significant difference (P <0.05). Three lesions thansingle and double vessel disease cystatin C levels (P<0.05).3.ST-segment elevationacute myocardial infarction and acute non-ST-segment elevation difference betweencystatin C levels in the myocardial infarction group no significant (P>0.05). Non-STsegment elevation acute myocardial infarction cystatin C levels with acute ST-segmentelevation myocardial infarction cystatin C levels were compared with the control groupthere was a significant difference.4. Acute myocardial infarction single, double, triplevessel disease cystatin C levels were also significantly different compared with controlgroup (P <0.05). Single, there were significant differences (P<0.05) between thetwo-branch and three-vessel disease in patients with acute myocardialinfarction.5.Unstable angina and coronary artery disease count cystatin C concentrationswere positively correlated (correlation coefficient=0.671, P<0.05). Acute myocardial infarction and coronary artery disease count cystatin C concentrations were positivelycorrelated (correlation coefficient=0.104, P<0.05).Conclusion:1.Cystatin C levels differ in different types of acute coronarysyndrome.2.Cystatin C levels and coronary lesion count related.3.Cystatin C level hasnothing to do with the type of acute myocardial infarction..4.Cystatin C may be thebiomolecular indicators of coronary lesions in acute coronary syndrome prediction. |
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