Study On The Association Between Tpeak-tend Interval And Left Ventricular Diastolic Function

Objective: to study the Tp-Te interval and its relationship with left ventricular diastolicfunction, evaluation of the correlation with Tp-Te interval and left ventricular diastolicdysfunction.Methods:(1) select patients who were diagnosed as left ventricular diastolic dysfunctionand diastolic heart failure with diagnostic criteria, then grouped into4groups by NYHAclassification; in addition，we selected normal people as control group according to sexand age;(2) we measured all of them Tpeak-Tend interval（Tp-Te），corrected Tpeak–Tend interval（Tp–Tec）and QT interval and corrected QT interval（QTc） in lead V2;(3) we also measured echocardiography indexes，including the left atrial diameter, leftventricular posterior wall thickness and interventricular septum thickness, left ventricularend-diastolic diameter and left ventricular ejection fraction;(4) we analyzed theassociation between Tp-Te interval and left ventricular diastolic dysfunction in patientswith NYHA classification, and the association between echocardiography data and leftventricular diastolic function.Results: Tp–Te interval and Tp–Tec in the left ventriculardiastolic dysfunction groups were significantly longer than control group, were116.97±22.65msVS102.26±20.02ms,125.09±25.69msVS111.06±22.44ms, P <0.05,Tp-Te, Tp-Tec are correlated with left ventricular diastolic dysfunction; And leftventricular diastolic dysfunction in patients with NYHA classification significantlypositively related to Tp–Te interval and Tp–Tec (Tp–Te γ=0.339,Tp–Tec γ=0.352,P <0.05). Patients with left ventricular diastolic dysfunction after its echocardiography ofleft ventricular wall thickness and interventricular septum thickness in NYHA grade Ⅳgroup cases compared with other cases have significant difference(P <0.05).Leftventricular ejection fraction decreased as the heart failure deteriorated(P <0.05).Other indexes such as the left atrial diameter, left ventricular end-diastolic diameter, thetraditional index reflecting ventricular repolarization discrete degree, QT and QTc werealso not significant in the groups of left ventricular diastolic dysfunction (P﹥0.05).Conclusion:1.Tp-Te and Tp-Tec were both significantly prolong in the left ventricular diastolicdysfunction group, have well correlation with left ventricular diastolic dysfunction.2.Tp-Te and Tp-Tec have significantly positive correlation with NYHA classification ofleft ventricular diastolic dysfunction in patients.