The Impact Of Total Flavonoids From Rose Chinensis On Diabetic Model

Objective: To study the therapeutic effect of total flavonoids from Rose chinensis ondiabetes model by establishing diabets model, and by measuriing glucose and lipidmetabolism index, antioxidant index and other related indexes, and observation thekidney, pancreas, thymus, spleen and other tissues of pathological morphologicalchanges. To investigate the total flavonoids from Rose chinensis therapy effect andfunction characteristics of the model.Methods: Establish the hyperglycemic mice model by intraperitoneal injection ofepinehrine; establish Diabetes Mellitus model of mice by tail vein injection ofstreptozotocin, hypogloeels vein injection of streptozotocin diabetic rats established;added feeding with formula feed characterized by high fat and sugar and byhypogloeeis vein injection of streptozotocin to establish type2diabetes model of rats.By measuring glucose, liver glycogen, glycosylation of serum protein, insulin. insulinantibody, triglyceride, total cholesterol, high-density lipoprotein, low-densitylipoprotein, superoxide dismutase, malondialdehyde, creatinine, blood urea nitrogen,urinary protein and other indicators. and to observe the pathological changes ofpancreas, kidney. Liver,thymus.Results:: Diabetes model are copied successfully.1.The influence on hyperglycemia mice model Compared with the model group, metformin group and the total flavonoids of rose for each dose group couldsignificantly lower blood level of animals, increased glycogen content.2.The influence on diabetes model by intravenous injection of streptozotocinCompared with the model group, metformin and the total flavonoids of rose in eachdose group can lower blood glucose animals, increased liver glycogen and glycatedserum protein content; stimulate insulin secretion; lowering triglycerides、cholesterol、NO levels and NOS levels; elevated SOD activity to increase antioxidant capacity ofthe body，improve the pancreas,kidneys,liver pathological changes.3.The influence on Ⅱdiabetes model by tail vein injection of streptozotocin andadded feeding with formula feed characterized by high fat and sugar Comparedwith the model group, metformin and the total flavonoids of rose can reduce bloodglucose, improve the body’s fat metabolism, increased SOD activity, reduce theamount of creatinine, urine protein, urea nitrogen,improve the pancreas,kidneys,thymus,spleen pathological changes.Conclusion: The total flavonoids can reduce blood sugar、 glycated serum proteinlevels, lower triglycerides, cholesterol levels, improving the body’s fat metabolism;promote insulin secretion and glucogen synehesis; can reduce the level of serum MDA;enhance the body clears freedom ability, reduce NO content and NOS activity, canimprove insulin resistance.