Evaluation Of The PAS Value In Patients With Prostate Cancer

Objectives: To evaluate the value of the prostate specific antigen(PSA),Free/TotalPSA(F/T),and the PSA density(PSAD) in the prostate cancer screen.Methods: This study selected208patients with prostatic diseases from July2011to August2012， who were diagnosed by prostate biopsy and/or pathologicalexamination of surgical specimens.According to the result of pathologicexamination,those patients was divided into prostate cancer (malignant group) andbenign prostate hyperplasia group (benign group)；According to the results of TURS，those patients was divided into nodules group(positive） and non nodulesgroup(negative）；According to the characteristics of the echo，those patients wasdivided into low echo group and high（mixed）echo group； Total serum PSAand freePSA were detected，the volume of prostate was measured by TRUS，F/T ratio andPSAD were calculated in those patients.According to the level of PSA (ng/ml)，thosepatients was divided into5groups,including PSA<4，4≤PSA<10，10≤PSA<20，20≤PSA <30and PSA≥30.Comparing the sensitivity、the specificity and theYouden’s index of different thresholds of PSA、F/T ratio and PSAD,optimum PSA,F/T ratio and PSAD for detecting prostate cancer were discussed.Results: PSA、PSAD and low level echo tubercle in patients with prostate cancerwere significantly higher than those in patients with benign prostatic hyperplasia（P＜0.01）.When the cue off value of PSA were set as4ng/ml、10ng/ml、20ng/ml or30ng/ml，the sensitivity of each one were94.03%、84.33%、67.16%、56.72%，andthe specificity of each one were31.08%、78.38%、93.24%、97.30%，and the Youden’s index of each one were0.2571、0.6271、0.604、0.5402；When the cue off value of F/Twere set as0.16、0.18or0.20，the sensitivity of each one were71.64%、73.88%、76.87%，and the specificity of each one were67.57%、64.86%、58.11%，and the Youden’s index of each one were0.3921、0.3874、0.3498；When the cue off value of PSAD（ng/ml/cm3） were set as0.15、0.25or0.35，the sensitivity of each one were88.81%、80.60%、73.88%，and the specificity of each one were68.92%、87.84%、95.95%，and the Youden’s index of each one were0.5733、0.6844、0.6983.Conclusions: In this study，the cue off value of PSA was set as10ng/ml, the cueoff value of F/T was set as0.16and the cue off value of PSAD as0.35ng/ml/cm3,thesensitivity,the specificity and the Youden’ s index were higher than othergroups.composite analyze PSA,F/T ratio and PSAD could promote the accuracy in thediagnosis of prostate cancer.