The Association Of Plasma Membrane Ca²⁺-ATPase Isomer2Gene （PMCA2） Polymorphisms With The Development Of Sudden Deafness

Objectives:To investigate the association of plasma membrane Ca2+-ATPase isomer2gene (PMCA2) polymorphisms with the development of sudden deafness.Methods:Totally,164patients were investigated and hearing tests. According to the results of audiometry, they were divided into two groups,sensorineural hearing loss group and normal hearing group. Polymorphisms of two single nucleotide loci rs2289274and rs6790640in the PMCA2gene were determined by polymerase chain reaction followed by allele specific amplication analysis in82patients with sudden deafness and82patients with normal hearing.Results:Frequencies of genotypes AA,AG and GG in the rs2289274locus were55.8%,17.4%and26.8%, respectively, in the sensorineural hearing loss group and26.8%,28.0%and45.2%, respectively, in the normal hearing group, and frequencies of alleles A and G in the same locus were64.5%and35.5%, respectively, in the sensorineural hearing loss group and41.1%and58.9%, respectively, in the normal hearing group. And, frequencies of genotypes CC,CT and TT in the rs2289274locus were18.3%,35.4%and46.3%, respectively, in the sensorineural hearing loss group and2.4%,63.4%and34.1%, respectively, in the normal hearing group, and frequencies of alleles C and T in the same locus were36.3%and63.7%, respectively, in the sensorineural hearing loss group and34.1%and65.9%, respectively, in the normal hearing group.Conclusion:It is suggested that genetic polymorphism of the rs2289274and rs6790640loci in the PMCA2gene might be a susceptible factor for sudden deafness.