Study On The Prevalence Survey And The Characteristics Of Event Related Potentials On PMDD With Liver Qi Invasion And Liver Qi Stagnation Syndrome

Objective：To investigate the prevalence of premenstrual dysphoric disorder(PMDD)with liver Qi invasion syndrome and liver Qi stagnation syndrome in the girls of grade2013of Henan University of Traditional Chinese Medicine, together with thedistribution of personality types and inhibitory control function between the twosyndrome types. Further enrich the TCM theory of liver regulating emotions, andprovide new clues to the study of central nervous system of PMDD with the twosyndromes.Methods：1Clinical epidemiological investigation method was applied to conduct aquestionnaire survey on2013Henan University of Traditional Chinese Medicine7department’s2302female college students, patients with PMDD and PMDD with liverQi invasion or liver qi stagnation syndrome were diagnosed by the preliminaryscreening of PMDD clinical volunteers into the screening scale combined with expertdiagnosis; Chinese adult version of the Eysenck Personality Questionnaire Revised byProfessor Gong Yaoxian in1983was used to make the investigation of personalitytypes.2PMDD liver Qi invasion and liver qi stagnation syndrome patients were selectedas subjects. Differences in behavioral inhibition function were compared between thetwo syndromes patients by using E-prime and Neuroscan system with bidirectionaloddball paradigm acquisition analysis subjects EEG. Behavioral data analysis was usedindependent samples t test, amplitude and latency data analysis was used four factorsrepeated statistical analysis of variance.Results：1The prevalence rate of PMDD of2013Henan University of Traditional Chinese Medicine freshman girls was15.7%; PMDD with liver qi invasion, liver Qi stagnationsyndrome accounted for31.1%and34.4%respectively.2There was statistically significant difference between the two groups of subjectswithin introverted instable emotion and extroverted instable emotion type ofpersonality. Liver Qi invasion group within introverted instable emotion typeaccounted for26.9%, extroverted instable emotion type accounted for53.7%; liver qistagnation syndrome group within introverted instable emotion type accounted for52.5%, extroverted instable emotion type accounted for25.4%.3ERPs behavioral data show that, the deviant stimulus response time of PMDDwith liver Qi invasion and liver qi stagnation syndrome subjects were both longer thanthe standard stimulus whether before or after menstruation, and the correct rate werelower than the standard stimulus.4Both PMDD liver Qi invasion and liver qi stagnation syndrome patients weresuccessfully induced N1, P2, N2, P3component, which related to conflict detection,inhibitory control processes.5A significant interaction existed between N1amplitude menstrual factors anddifferent groups, the simple effect analysis showed that there was no differencebetween different groups and menstrual factor level.6Comparison of P2differential waves showed, liver qi invasion group wassignificantly larger than the liver qi stagnation syndrome group after menstruation, thelatency of P2in patients with liver qi invasion group has long trend than liver qistagnation syndrome group. This suggested that patients with liver qi invasion groupcan make cognitive processing rapidly to the involved target stimulus, then mobilizethe brain related attention resource, and showed that the depth of processing of targetstimuli deeper than liver qi stagnation syndrome group; Two groups of subjects weresuccessfully induced N2components, but the difference was not statisticallysignificant, suggesting that the two groups of subjects’s ability on the conflictmonitoring to the target stimulus equivalently.7Comparison of P3differential waves showed, liver qi stagnation syndromegroup were bigger than the liver qi invasion; After menstruation liver qi invasion groupsubjects the difference of P3wave amplitude was significantly smaller than the former,suggesting that inhibitory control ability of the liver qi invasion group subjects betterthan liver qi stagnation syndrome group under the negative emotional conditions, andafter menstruation, along with the heart-body symptoms relieved or disappeared, inhibitory function recovery obviously.Conclusion：12013Henan University of Traditional Chinese Medicine freshman girls had highprevalence of PMDD, which up to15.7%, school and the society should pay moreattention to this situation. PMDD patients with liver qi invasion and liver qi stagnationsyndrome accounted for the investigation of PMDD31.1%and34.4%respectively; theliver is the main pathological mechanism of PMDD.2PMDD with liver qi invasion and liver qi depression patients were associatedwith emotional instability, liver qi invasion were mostly extroverted emotionallyunstable personality type, and stagnation of liver qi group to introverted emotionallyunstable personality.3The Inhibition ability of PMDD with liver qi invasion group was stronger thanthat of liver qi stagnation syndrome group, which had more obviously advantages aftermenstruation.