Comparison Of Efficacy Of Ketamine And Dexmedetomidine For Prevention Of Catheter Related Bladder Discomfort In General Anesthesia

Objectives:This topic aims to compare of efficacy of preemptive administration of Ketamine and Dexmedetomidine for prevention of catheter related bladder discomfort in general anesthesia to evaluate the effectiveness and superiority of the treatment of CRBD.Methods:Altogether90male patients, American Society of Anesthesiologists physical status class Ⅰ or Ⅱ, undergoing elective surgical procedures requiring urinary bladder catheterization were randomized into three equal groups of30each. Group C(control) received normal saline20ml; Group K(Ketamine) received Ketamine0.3mg/kg and group D(Dexmedetomidine) received Dexmedetomidine0.5μg/kg.Group D and group C were respectively diluted in20ml NS and given continuous intravenous infusion in10min with micromedicine infusion-pump near the end of the operation. They were extubated in the operating room after surgery and transferred to the postanesthesia care unit(PACU) for recovery. The bladder discomfort was assessed at0,1,2and6h after patient’s arrival in the post-anesthesia care unit。Severity of bladder discomfort was graded as mild, moderate and severe. And all of the patients conducted the level of Ramsay, VAS and were recorded the incidence of postoperative side reactions in the3groups.Results:1. Group K and group D had a significantly lower incidence than group C (P<0.05) at every time point. The CRBD incidence in group D and group K had no significant differences (P>0.05). Compared with group C, there was significant difference in the severity between group K and group D (P<0.05) at every time point, while they had no difference (P>0.05);2. VAS pain score in group D and group K were much lower than group C all the time, while they had no difference (P>0.05);3. Compared with group C and group K, Ramsay sedation score in group D was much higher at0,1and2h (P<0.05). Ramsay sedation score in group C and group K had no statistic significance (P>0.05)Conclusions:Pretreatment with either Dexmedetomidine (0.5μg/kg) or small dose of Ketamine(0.3mg/kg) could significantly reduce the incidence and severity of postoperative CRBD, while they had no difference; intravenous infusing Dexmedetomidine (0.5μg/kg) was observed higher incidence of mild sedation with no side effects.