Comparison Of Efficacy Of Oxycodone And Fentany For Prevention Of Catheter Related Bladder Discomfort :a Prospective, Randomized,Placebo-controlled,Double-blind Study

Objectives:The aim of this randomized controlled trial was to evaluate the efficacy and safety of intravenous oxycodone and fentanyl in alleviating the catheter-related bladder discomfort (CRBD) in postoperative patients after general anesthesia.Methods:A total of 80 adult patients, American Society of Anesthesiologists physical status I and â…¡, were randomized into two equally sized groups (n=40), oxycodone group(group O) and fentanyl group(group F). These two groups were assigned to give either intravenous oxycodone 0.08 mg/kg or fentanyl 0.8ug/kg as placebo 10 min before the end of the operation. In the postoperative period, patients were catheterized with a 16Fr or 20Fr catheter. Grading of CRBD was done as none, mild, moderate and severe by a blinded observer at 0,30min, lh,2h and 6h after operation. MBP, HR and VAS were assessed during recovery period in PACU. The study also compared the incidence of postoperative nausea and vomiting, sedation, and respiratory depression in the 2 groups.Results:1. Incidence and severity of CRBD was reduced in oxycodone group compared with fentanyl group at 0,30min and 2h (P<0.05).2. Hemodynamic of oxycodone group is more smooth, and lower incidence of moderate or severe CRBD in oxycodone group compared with fentanyl group.3. Postoperative pain as assessed by visual analogue scale was also reduced in the oxycodone group compared with fentanyl group at 2h after operation (P<0.05).4. Extubation time and postoperative side effects were similar in both the groups (P>0.05).Conclusion:Intravenous injection oxycodone is an effective treatment for reducing the incidence and severity of postoperative CRBD.