| Senile dementia, i.e. Alzheimer’s disease,is a kind of brain disorder caused by cerebrum organic lesion, it’s a nervous system degenerative disease. In view of the clinically symptom such as memory loss, looked sluggish, mental disorders, slow response, movement disorders and so on, TCM etiology and pathogenesis of Alzheimer’s disease perspective is that liver kidney yin insufficiency Is the basis of the incidence of the disease, phlegm and static blood blocking orifices Is a key factor in the pathogenesis of the disease. In addition, emotional factors and physical factors peculiar to the elderly also associated with the occurrence of the disease. In modern medicine, the disease is a continuous course of the disease comprising mild cognitive impairment, full-blown recession on cognitive decline is clinical features. Although the specific pathogenesis is not entirely clear, but it’s closely related with β-amyloid deposition, Tau hyperphosphorylation, nerve inflammation, oxidative damage and apoptosis. In pathology, senile plaques, neurofibrillary tangles and neuronal loss is three main feature.The experiment produced AD cell model induced by A025-35in rat hippocampal neurons, set Gai Liang San Jia San cerebrospinal fluid group as medicated treatment group, set huperzine as comparison group, to research the protection mechanisms to cell injury of Gai Liang San Jia San on AD rat model. It was found that lactate dehydrogenase levels increased in cell supernatant of AD cell model, described existence of neuronal injury. Further experiments found that cholinergic system damage also exist in AD cell models, as well as the overactivation of nuclear factor kappa B and c-jun N-terminal kinase. After treatment Chinese medicine, the results show Gai Liang San Jia San on cells of rats AD has a good protective effect, the mechanism may be improving central cholinergic nervous system function, Suppressing the excessive activation of NF-κB signaling pathway and the ctivation of JNK signaling pathway. |
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