Correlation Between Nonalcoholic Fatty Liver Disease And Bone Mineral Density In Postmenopausal Women

Objective:To evaluate the correlation between non-alcoholic fatty liver disease and bone mineral density in postmenopausal women in Urumqi.Methods:A total of122middle-aged and elderly postmenopausal women hospitalized in our Hospital were classified into the non-alcoholic fatty liver disease group(the NAFLD group) and the normal control group (58cases in the NAFLD group and64cases in the control group).The data including the ratio of CT values of the liver and spleen, bone mineral density at the1-4lumber spines, the left femur neck, greater trochanter, Wards’triangle and total hip, height, weight as well as blood biochemical indexes of all the subjects were collected and statistical analyses were performed.Results:(1)Weight, body mass index(BMI) and triglyceride(TG) were higher in the NAFLD group than in the normal control group, and low-density lipoprotein (LDL) was lower in the NAFLD group than in the normal control group (P<0.05).(2) After adjusting age and BMI:a. Results of the covariance analysis showed that:the BMD at1-4lumbar spines and each site of the left hip(femur neck, greater trochanter, Wards’triangle and total hip) were lower in the NAFLD group than in the normal control group, and there was statistical difference at each site of the left hip(femur neck, greater trochanter, Wards’ triangle and total hip)(P<0.05). b. Results of the linear regression analysis showed that:(1)the ratio of CT values of the liver and spleen was positively associated with BMD at each site of the left hip(femur neck, greater trochanter, Wards’ triangle and total hip) in the NAFLD group(P<0.05). There were no correlation between the ratio of CT values and BMD in the normal control group.(2)Lipoprotein(a)[LP(a)] and LDL were closely associated with BMD in the normal control group:LDL was positively associated with BMD at the1-4lumbar spines and each site of the left hip(femur neck, greater trochanter, Wards’ triangle and total hip) in the normal control group(P<0.05). LP(a) was significantly and negatively associated with BMD at each site of the left hip(femur neck, greater trochanter, Wards’triangle and total hip) in the normal control group(P<0.05). LDL and LP(a) have no correlation with BMD in the NAFLD group.(3)Triglyceride(TG), total cholesterol(TC) and high density lipoprotein (HDL) have no relevance to BMD at the1-4lumbar spines and each site of the left hip(femur neck, greater trochanter, Wards’ triangle and total hip) in both the NAFLD group and the normal control group(P>0.05).Conclusion:(1)Reduced BMD at the hip and lumber spines in postmenopausal women with NAFLD is related to the severity of fatty liver. NAFLD is a risk factor for low bone mass and osteoporosis.(2)NAFLD may change the effects of LDL and LP(a) on BMD in postmenopausal women.(3)LDL may protect the normal postmenopausal women without NAFLD from bone loss. High LP(a) is a risk factor for low bone mass in the normal postmenopausal women without NAFLD.