Probiotic Supplementation Increases Helicobacter Pylori Eradication Rate: Evidence From A Meta-analysis

Objective: To broadly evaluate the effect of eradication regimenssupplemented with probiotic on eradication rates and adverse effects.Methods： We identified the eligible articles by widely retrieval.Statistical analysis was performed with Review Manager5.2. Outcomes were finallyevaluated by GRADE system.Results: Nine RCTs of high-quality met eligible criteria. Risk ratio oferadication was available for1163patients. Lactobacillus-containingprobiotics significantly increased the eradication rate compared with thecontrol group based upon intention-to-treat analysis [RR=1.14;95%CI(1.06–1.22)] by the fixed effect model without significant publication bias,but the significant reduction associated with overall side effects was notobserved [RR=0.88;95%CI(0.73–1.06)]. In the subgroup analysis,eradication rates raised significantly by17%in lactobacillus administratedalone group [RR=1.25;95%CI (1.13–1.37)]. In multistrain probioticsgroup, eradication rates enhanced only2.8%[RR=1.04; 95%CI(0.94–1.14)]. It also showed that lactobacillus-containing probioticsimproved the eradication rates, respectively, both in adults[RR=1.12;95%CI(1.04–1.20)] and in children [RR=1.25;95%CI(1.01–1.53)].Conclusions: Lactobacillus-containing probiotic as an adjunct iseffective to eradication therapy, while side effects caused by eradicationtreatment may not decrease. Furthermore, lactobacillus administrated alonewill distinctly benefit eradication therapy.