Clinical Value Of Detection Of Serum5’-nucleotidase,Total Bile Acids And γ-glutamyl Transferase In Patients With Hepatic Disease

Objective:To investigate the clinical value of serum levels of5’-nucleotidase (5’-NT), total bile acids (TBA), y-glutamyl transferase (GGT) and Alanine amino transferase (ALT) in patients with hepatic disease. Methods:The serum levels of5’-NT, TBA, GGT and ALT were measured by BECKMAN AU5821. Results:Compared with healthy controls, the serum levels of5’-NT, TBA, GGT and ALT in these patients were significantly higher (P<0.01). Compared with chronic viral hepatitis,the serum levels of5’-NT in liver cirrhosis and in liver cancer were significantly higher (P<0.05). Compared with chronic viral hepatitis and liver cancer, the serum levels of TBA in liver cirrhosis were significantly higher (P<0.05, P<0.01). Compared with chronic viral hepatitis and liver cirrhosis, the serum levels of GGT in liver cancer were significantly higher (P<0.01). Conclusion:especially cannot reflect the conditions of liver tissues damage. Low levels of ALT is considered risk factors of chronic viral hepatitis with liver cirrhosis and liver cancer. Persistence of elevated5’-NT, GGT are of usefulness in monitoring chronic viral hepatitis with liver cirrhosis and liver cancer. Moreover significant increased GGT in chronic viral hepatitis and liver cirrhosis should be on the alert for liver cancer. TBA can reflect sensitively the liver’s anabolic function in liver cirrhosis patients. The serum levels of5’-NT, TBA, GGT can reflect sensitively the levels of hepatocyte damage and acute liver dysfunction. To determine the levels of5’-NT、TBA、GGT has important significance for diagnosis, identification and monitoring of hepatic disease.