Study Of The Change And Influencing Factor Of Serum Bilirubin In Patients With The Metabolic Syndrome

Objective To study the change of serum bilirubin，and explore the association of serumbilirubin and components and target organ damage in patients with the metabolic syndrome.Methods To examine the level of serum total bilirubin，direct bilirubin，indirect bilirubinof30cases metabolic syndrome patients and the30cases control group，then campanison wasdone between the two groups.To analyze the relationship between serum bilirubin and fastinglipids and blood glucose (FPG)，blood pressure，and waist circumference，left ventricularmass index (LVMI)，flow velocity of Middle cerebral artery (MCAVs) and creatinineclearance(Ccr).Results1.The serum total bilirubin，direct bilirubin，indirect bilirubin in MS group waslower than in normal people；2.Serum total bilirubin level was highly significant negativecorrelated with TG、waist circumference、FPG，and a significant positive correlation betweenserum total bilirubin and HDL-C；serum direct bilirubin level was significant negativecorrelated with TG；serum indirect bilirubin level was significant negative correlated withTG、waist circumference、FPG，and a significant positive correlation between serum indirectbilirubin and HDL-C；3. LV、IVS、LVPW、LVM、LVMI in MS group increased significantlycompared with normal group，Ccr、MCAVs and ICAVs in MS group decreased comparedwith normal group；4.Serum total bilirubin level was significant negative correlated withLVMI，and a significant positive correlation between serum total bilirubin and Ccr、MCAVsand ICAVs；serum indirect bilirubin level was highly significant positive correlated withMCAVs and ICAVs；The higher serum total bilirubin and indirect bilirubin level the fasterICAVs；5.The higher serum total bilirubin level the less target-organ damage. Conclusion The results indicated that serum bilirubin level was closely related to thecomponents and its target organ damage in patients with MS.