| Objectives To Analyze plasma P-selectin and NT-pro-BNP levels in patients with acutecoronary syndrome（ACS）. Understand PS and NT-pro-BNP levels in different typesof ACS. evaluate the relationship between plasma P-selectin and NT-pro-BNP levels withthe degree of coronary artery stenosis.Analysis of the relationship between PS and NT-pro-BNP. In order to investigate the relationship between plasma P-selectin and NT-pro-BNP levels with major adverse cardiac events（MACE）of six months followed up inACS patients. Discussion the risk factors of MACE in ACS patients.Methods Select318cases patients with chest pain from June2012to January2013incardiology of Tangshan gongrens’ hospital,211case of male, female patients107case,with an average age of58.2±10.5years old. Cubital vein taken immediately on admission,Determine plasma NT-pro-BNP using enzyme-linked immunosorbent assay, The kit wasproducted by Shanghai gongshuo Bio-Technology company. plasma PS levels using thesame ELISA and kit by Tony instruments are Nanjing limited liability company. All thePatients are to be coronary angiography and split into control group （non-CHDgroup）80cases,147cases was unstable angina and acute myocardial infarction（including acute non-ST segment elevation myocardial infarction, acute ST-segmentelevation myocardial infarction）91cases according to angiographic results, ECG andcardiac enzymes results. Each row to be selected by Gensini score based on the results ofcoronary angiography and to evaluate the degree of stenosis according to Gensini scoreand number of lesions. ACS patients were followed up for6months to track patientsMACE events （including unstable angina, myocardial infarction and sudden cardiacdeath）occurred, loss follow-up of3cases. Application epidate establish a database,analysis using SPSS13.0, count data groups were compared using the chi-square test,measurement data between the two groups using t test, comparison between multipleanalysis of variance, non-normally distributed data using non-parametric tests, relationsbetween the two analyzed using bivariate correlation analysis and linear regressionanalysis, analysis of related factors for the occurrence of MACE in patients with ACSand ACS by logistic regression. Analysis of each group NT-pro-BNP and PS levels.Clear relationship between NT-pro-BNP and PS between evaluate NT-pro-BNP and PSwith coronary stenosis and six-month follow-up MACE events relationships.Result ACS group and the control group PS levels were14.87±3.09ug/L,41.57±11.89ug/L, P <0.001, with significant differences. NT-pro-BNP mean rank were70.63，188.54，P <0.001, with significant differences. ACS is closely related to PS andNT-pro-BNP, the OR values were estimated as1.058（95%CI1.002~1.117, P<0.05）,2.603（95%confidence interval of1.335~5.075, P <0.05）. The controlgroup, unstable angina and acute myocardial infarction PS level group were14.87 ±3.09ug/L,38.15±10.90ug/L,47.09±11.89ug/L, unstable angina and acutemyocardial infarction Compare the difference with the control group, there was asignificant, unstable angina and acute myocardial infarction group there was a significantdifference. NT-pro-BNP mean rank were73.11，159.46，235.51，unstable angina andacute myocardial infarction in comparison with the control group and had significantdifference, unstable angina and acute myocardial infarction group had significantdifference. ACS Patients PS, NT-pro-BNP levels and coronary Gensini score wassignificantly positively correlated, R values respectively0.659,0.446, P<0.001. PS, NT-pro-BNP and Gensini score multiple linear regression analysis showed that the regressioncoefficient±standard error, respectively:3.255±0.24,0.009±0.01, P<0.001. ACSpatients who has Single vessel, two-vessel and three lesions PS level were32.68±10.02ug/L,43.30±9.57ug/L,51.39±10.04ug/L, double vessel, three vessel comparewith single-vessel has significant difference, Compared to double-vessel disease withthree relatively significant differences also exist. NT-pro-BNP mean rank were96.04,113.82,165.19, there was a significant difference in double vessel disease, threewith single-vessel disease, compared to double-vessel disease and three comparison thereare also significant differences. PS and NT-pro-BNP showed a significant positivecorrelation, R value of0.284, P <0.001. MACE group and non-MACE group PS levelswas52.95±8.87ug/L,36.38±13.10ug/L, had a significant difference （P <0.001）.MACE group and non-MACE group NT-pro-BNP average rank were197.98,102.19,with a significant difference （P <0.001）, Logistic regression found that NT-pro-BNP,PS, Gensini score and number of lesions are MACE risk factors, the OR estimates were1.001（95%confidence interval1.000~1.001, P <0.05）,1.059（95%confidenceinterval1.002~1.120, P <0.05）,1.046（95%confidence interval1.020~1.073, P<0.001）,6.712（95%confidence interval of1.614~27.913, P <0.05）.Conclusions1ACS patients PS and NT-pro-BNP levels were significantly higher thancontrol group, acute myocardial infarction> unstable angina group> control group.2ACSis closely related to PS and NT-pro-BNP.3ACS patients PS and NT-pro-BNP levels andcoronary Gensini score positive linear correlation, With the increase in the number ofdiseased vessels PS and NT-pro-BNP levels increased.4PS was positively correlatedwith NT-pro-BNP in ACS patients.5ACS patients had the higher MACE in sixmonths,who had the higher PS and NT-pro-BNP levels.6The risk factors of MACEwith ACS patients were NT-pro-BNP, PS, Gensini score and count the occurrence oflesions in patients with ACS. |
PDF Full Text Request