| ObjectiveThis study was to collect samples of patients hospitalized for bacterial infection of cultured bacteria isolated rate statistics and sensitivity rate and resistance rates to commonly used antibiotics, analysis of resistance changes and the trend of sputum samples isolated from the main pathogens, specifically hospital infection patients with bacterial distribution and drug resistance. MethodsPatients infected from January 2011 to December 2013 in one hospital were collected in specimens for bacterial culture and sensitivity test, statistical isolated non-recurring types of bacterial infections and drug resistance. Then samples isolated five most common bacteria to represent, analyze changes in common bacterial to commonly used antibiotics resistance. Bacterial identification and antibiotic susceptibility testing using automated microbial analyzer VITEK32, susceptibility identified by broth dilution method. The results were judged and divided into sensitive(S), intermediaries(I), resistance(R) according to CLSI criteria edition of 2010. Statistical analysis used software of WHONET bacterial resistance monitoring network of WHO. Results 1 Constitute of pathogenA total of 47308 cases were collected from February 2011 to October 2013. Gram-negative bacteria dominated the highest in pathogen isolated, the proportion were 68.1%, 68.9%, 67.7%. followed by Gram-positive bacteria, the proportion were 26.1%, 28.0%, 26.8%. fungus was minimum.。 Escherichia coli, Acinetobacter and Pseudomonas aeruginosa are the most common in Gram-negative bacteria. Staphylococcus aureus is the most common of the Gram-positive bacteria. 2 Gram-negative bacteria sensitive to the antibiotic resistance rates and the rate of DiPseudomonas aeruginosa have highest resistance rate to gentamicin, resistance rates were 50.6%, 49.9% and 40.7% respectively from 2011 to 2013. Polymyxin B resistance was lowest and the resistance rate was 2.7% and 3.8%, respectively, and did not detect in 2013; Escherichia coli and Acinetobacter baumannii resistant to most antibiotics rate is higher, but the combination preparation resistance is low. E. coli resistance rates meropenem and imipenem from 2011 to 2013 were 0.6%, 0.9%, 1.3% and 0.7%, 1.2%, 1.5%, Acinetobacter baumannii multi stick avermectin B resistance rates in 2011 and 2012 resistance rate of 3%, 2.3%, and was not detected in 2013; Klebsiella pneumoniae comparison to most cephalosporins, sulfonamides and quinolone resistance rates high, but cefoperazone/sulbactam and piperacillin/ tazobactam resistance rates in 2011 and 2013 are 17.5%, 28.3%, 5.4% and 15.9%, 29%, 19.2% from 2011 to 2013. 3 Gram-positive bacteria sensitivity and resistance rates to antibioticsStaphylococcus aureus have highest resistance rate to azithromycin, erythromycin, penicillin G from 2011 to 2013 for azithromycin resistance rate was 86.9%, 84.8% respectively, and was not detected in 2013. Erythromycin resistance rates were 85.7%, 82.2%, 79.1%, resistance rates to penicillin G was 96.5%, 97.2%, 97.5% respectively; pension aureus teicoplanin, linezolid, vancomycin almost completely insensitive from 2011 to 2013. gold aureus resistance rate of teicoplanin are 0% in 2011 and 2012, 1.1%, and was not detected in 2013. From 2011 to 2013 the rate of resistance to linezolid and vancomycin are 0%. Conclusions1 Pathogens isolated from infected patients hospitalized of 2011 to 2013 mainly is Gram-negative bacilli, Gram-positive bacteria followed;2 Three years, the rate of Gram-negative bacilli resistant to antibiotics constantly changing. Currently still have good sensitivity rate to Carbapenem antibiotics and β- lactamase inhibitor complexing agent.3 Three years, the rate of Staphylococcus aureus resistant to antibiotics are constantly changing, the sensitivity of vancomycin, teicoplanin and linezolid fell amines is high. |
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