Exploration Of The Relationship Between Childhood Asthma And Mycoplasma Pneumoniae Infection:a Systematic Review

Objective Mycoplasma pneumoniae (MP) infection has been considered a risk factor induced asthma in children. To explore the relationship between MP infection and asthma, we intend to research the case-control literature published at home and abroad database that explore relationship between MP infection and asthma, by using Meta analysis.Method Using the Cochrane system evaluation method, retrieval and study all the relevant articles which search form Cochrane Library, PubMed, CNKI, VIP, Wanfang total 5 domestic and foreign databases during the database began to set up to 2015 March. Then, two workers independently assessed the methodological quality of the included studies and extracted data. The use of CMA V2 (Comprehensive Meta-analysis V2) software for statistical analysis. For publication bias was assessed by funnel plot. Using Begg’s and Egger’s test for quantitative detection of publication bias.Use the "trim and fill" to detect publication bias and the effect of the corrected values.Result Finally included 26 eligible studies, involving 2582 cases and 2201 cases of control. The results showed that in asthma group, the incidence of MP infection was higher than that in control group, and the MP infection in children than without MP infection, the incidence of asthma was increased 2.75 times (OR=3.75,95%CI=3.21～4.39, P< 0.001). This result is stable, but there is a publication bias in our Meta analysis.Conclusion MP infection can increase the morbidity of children’s bronchial asthma (an increase of 2.75 times).