Clinical Research Of Computed Tomography Perfusion And Magnetic Resonance Spectroscopy In Patients With Traumatic Subarachnoid Hemorrhage

Partâ… :The effect of lumbar continuous drainage on cerebral computed tomography perfusion in patients with traumatic subarachnoid hemorrhageObjective: To explore the effect of lumbar continuous drainage on cerebral computed tomography perfusion and clinical outcomes in patients with traumatic subarachnoid hemorrhage(t SAH).Methods: Thirty-two patients with t SAH, admitted to our hospital, were divided randomly into 2 groups(n=16): control group(giving conventional treatment) and treatment group(performing lumbar continuous drainage). CT cerebral perfusion imaging was performed on the 3rd, 7th and 14 th day of t SAH; parameters as cerebral blood volume(CBV), cerebral blood flow(CBF), time to peak contrast agent(TTP) and mean transit time(MTT) were collected. Clinical follow-up was performed six months after treatment. The differences of cerebral perfusion parameters and clinical outcomes of the two groups were compared and analyzed statistically.Results: The CBV and CBF were significantly higher and TTP and MTT were significantly lower in the treatment group than those in the control group on the 7th day of t SAH(P<0.05). In the treatment group, the CBV and CBF were significantly decreased and TTP and MTT were significantly increased on the 7th d of t SAH as compared with those in the 3rd d of t SAH(P<0.05). The GOS scores in the treatment group was significantly higher than those in the control group 6 months after treatment(P<0.05). The treatment efficacy in the treatment group was obviously better than that in the control group(average rank: 16.63 vs 12.04). The cases of cerebral infarction and hydrocephalus in the treatment group(0 and 1) were lower than those of control group(1 and 2).Conclusions: TSAH resulted in cerebral vasospasm, and then, reduced the cerebral blood perfusion. Lumbar continuous drainage can relieve cerebral vasospasm, improve cerebral blood perfusion, decrease the complications and improve the outcomes of t SAH patients.Partâ…¡:The effect of lumbar continuous drainage on cerebral magnetic resonance spectroscopy in patients with traumatic subarachnoid hemorrhageObjective: To explore the effect of lumbar continuous drainage on regional cerebral metabolism, cognitive dysfunction and clinical outcomes in patients with traumatic subarachnoid hemorrhage(t SAH).Methods: Group A(control group) include ten cases of traffic accident patients without brain contusion and hemorrhage on CT. Fifty-seven patients with t SAH,admitted to our hospital, were divided randomly into 2 groups, group B(n=28,giving conventional treatment), group C(n=29,giving conventional treatment and lumbar continuous drainage). Three groups accepted magnetic resonance spectroscopy examination and clinical dementia scale(CDR) at the 10 th day after traumatic brain injury and clinical follow-up after treated 3 months; parameters as N-acetylaspartate/Creatine(NAA/Cr), Choline/Creatine(Cho/Cr) and N-acetylaspartate/Choline(NAA/Cho) were collected. Group B and C accepted GOS scale at clinical follow-up after treated 3 months. The differences of cerebral magnetic resonance spectroscopy parameters and clinical outcomes of the three groups were compared and analyzed statistically.Results: The NAA/Cr and NAA/Cho were significantly higher and Cho/Cr were significantly lower in group C than those in the group B on the 10 th day of t SAH(P<0.05). The CDR scores were significant lower and GOS scores were significantly higher in group C than those in the group B after treated 3 months(P<0.05).Conclusions: Lumbar continuous drainage can improve the regional cerebral metabolism, cognitive dysfunction and clinical outcomes of patients with traumatic subarachnoid hemorrhage.