The Relationship Between Serum Uric Acid And Cerebral Apoplexy

Objective: There are five main characterizes of cerebral apoplexy in China, including higher morbidity, recurrence rate, mortality, disability and financial burden. And, its incidence is rising 8.7% each year. It has already been the first place in the cause of death in China. Therefore, this topic study the relationship between erum uric acid(SUA) and cerebral apoplexy to clear whether SUA is the risk factor for cerebral apoplexy,and provide theoretical basis for prevention and treatment of cerebral apoplexy.Method: 117 patients with cerebral apoplexy were selected. They were all paroxysm firstly within 48 hours. All patients met the standards of diagnostic criteria of the Sixth National Conference of Cerebrovascular Disease, and based on the strict neurological examination. All patients were excluded cerebral embolism, transient ischemic attack, and subarachnoid inferior vena bleeding by CT or MRI. They also were excluded cerebrovascular disease caused by trauma, vascular inflammation, vascular malformations, tumors, and blood diseases. Those patients who recently had a myocardial infarction, peripheral vascular occlusive disease, gout, trauma, surgery, diuretics, and high purine food were also excluded. They were divided into two groups according clinical categories. Group one is cerebral infarction, including 70 cases, 43 males and 27 females, respectively. The average of age in group one was 59.44±8.01. Group two was cerebral hemorrhage, including 47 cases, 28 males and 19 females, respectively. The average of age in group one was 56.74±9.01. At the same time, all two groups of patients were scored by the national institutes of health stroke scale(NIHSS). The score among 0-3 was mild, 4-15 was moderate and >15 was severe.The reference group includes 81 cases,which are our hospital healthy person with normal physical examination,48 males and 33 females with average age 57.63±8.41.Sex ratio and age structure, matched with the case group,without cardiovascular disease and cerebrovascular disease.Blood tests of all 117 cerebral apoplexy patients were finished in paroxysm 48 hours. And, those people in the reference group were taken blood sample from cubital vein in the morning to detect uric acid, glucose, total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein, apolipoprotein A1, and apolipoprotein B by Mindray BS-400 automatic biochemical analyzer, and Precil C2000-A automated coagulation analyzer was used to analyze plasma fibrinogen.The data source was collected and statistically analyzed by SPSS13.0.Result:1 SUA、TG、Apo-B、SBP、and DBP level of those patients in cerebral infarction group was significantly higher than those people in reference group(P<0.01); GLU、TC、and FIB level of those patients in cerebral infarction group was higher than those people in reference group(P<0.05); Apo-A1 and HDL-C level of those patients in cerebral infarction group was also significantly lower than those people in reference group(P<0.01); HDL-C、TC、Apo-A1、SBP、DBP level of those patients in cerebral infarction group was significantly lower than those people in cerebral hemorrhage group(P< 0.01);LDL-C level of those patients in cerebral infarction group was higher than those people in cerebral hemorrhage group(P<0.05);SUA level of those patients in cerebral infarction group was significantly higher than those people in cerebral hemorrhage group(P<0.01).2 The SUA level of those patients in severe cerebral infarction group was higher than those patients in moderate cerebral infarction group(P<0.05), the SUA level of those patients in moderate cerebral infarction group was also higher than those patients in mild cerebral infarction group(P<0.05),and the SUA level of those patients in severe cerebral infarction group was also significantly higher than those patients in mild cerebral infarction group(P<0.01).3 GLU、TG、TC, Apo-B、SBP、and DBP level of those patients in cerebral hemorrhage group was significantly higher than those people in reference group(P<0.01); SUA level of those patients in cerebral hemorrhage group was higher than those people in reference group(P<0.05); Apo-A1 level of those patients in cerebral hemorrhage group was also lower than those people in reference group(P<0.05).4 The SUA levels of those patients in severe and moderate cerebral hemorrhage group were significantly higher than those patients in mild cerebral hemorrhage group(P<0.01), and the SUA level of those patients in severe cerebral hemorrhage was also higher than those patients in moderate cerebral hemorrhage group(P<0.05).5 Multivariate Logistic regression analysis results show, SUA is a factor of cerebral infarction(OR=10.430,95%CI1.305~83.366,P<0.05),At the same time,SUA is a factor of cerebral hemorrhage(OR=3.106,95%CI 1.408~5.382,P<0.05).Conclusion:The high level of serum uric acid(SUA) is one of risk factor of cerebral apoplexy, especially in those patients with cerebral infarction.The level of serum uric acid(SUA) can indirectly reflect disease severity of cerebral apoplexy. There are positive relationship between SUA and the severity of cerebral apoplexy.Blood glucose, dyslipidemia, hypertension is an important risk factor for the occurrence of cerebral apoplexy, the dyslipidemia in cerebral infarction was more obvious, and the hypertension effect is more prominent for cerebral hemorrhage.Fibrinogen is closely related to the occurrence of cerebral infarction, but there is no significant correlation with cerebral hemorrhage.