The Correlation Of Syndrome Types Of Traditional Chinese Medicine And Cranio-Cervical CTA In Patients With Early Cerebral Infarction

Objective To explore the relationship between the syndrome types of traditional Chinese medicine and the cranio-cervical CTA in patients with early cerebral infarction. The risk factors that leading to extra-intracranial arteries atherosclerosis were analyzed. To provide objective basis for syndrome types of traditional Chinese medicine in patients with early cerebral infarction.Methods 130 cases of first episode of cerebral infarction with onset time within 72h hospitalized in the department of neurology from March 2014 to April 2015 were adopted. Traditional Chinese medical four diagnostic information were collected and the syndrome types of traditional Chinese medicine were made. The cranial-cervical CTA examination were performed subsequently. The data were analyzed by the static software SPSS 16.0. The differences about intracranial and extracranial atherosclerotic lesions between different syndrome types of traditional Chinese medicine in patients with early cerebral infarction were analyzed.Results 1. "Feng-tan-yuzu syndrome" is the most common of syndrome types of traditional Chinese medicine in patients with earlly cerebral infarction.2.2210 vessels segments were detected in 130 patients. The total narrow segments was 692(31.3%), and the intracranial narrow segments of which was 456 (20.6%), and the extracranial narrow segments was 236 (10.7%).Intracranial vessels were more easily involved than extracranial vessels (p< 0.05).3. The correlation between different TCM syndrome types and the number of affected arteries in patients with early cerebral infarction respectively was not significant (p> 0.05). Multiple segments were more easily involved than single segment in each syndrome type. Less segments were affected in "Feng-tan-yuzu syndrome" group and "Feng-huo-shangrao" group. Multiple segments involvement were found more frequently in "Wind formation from yin deficiency" group and "qi deficiency and blood stasis" group.4. The difference of artery stenosis between each TCM syndrome type was statistically significant (p< 0.05) in patients with early cerebral infarction. The artery stenosis was more severe in "Phlegm-heat accumulation" group than "Feng-tan-yuzu syndrome", "Wind formation from yin deficiency" group and "Qi deficiency and blood stasis" group.5. The difference of the character of atherosclerotic plaques between different syndrome types of traditional Chinese medicine in patients with early cerebral infarction was significant(p<0.05).487 artery plaques were found in 130 cases. In which there were 246 extracranial artery plaques (98 soft plaques, 26 hard plaques and 122 mixed plaques),and 241 plaques located in intracranial arteries (37 soft plaques,190 hard plaques and 14 mixed plaques). Hard plaques were more common in the intracranial artery,and soft plaques, mixed plaques in the extracranial artery, which the difference was statistically significant (P< 0.001).6. Multi-factor non-conditional Logistic regression analysis showed that the main risk factor leading to intra-extracranial artery stenosis was hypertension.Conclusions 1. Intra-extracranial atherosclerotic stenosis is one of the most important factors that leading to cerebral infarction and this is the same with the prior study. The stenosis of intracranial arteries is more severe than extracranial arteries and intracranial calcified plaques are more common than extracranial arteries in cerebral infarction patients in China.2. Wind, phlegm and blood stasis are the most important factors of early cerebral infarction. The syndrome types of traditional Chinese medicine in patients with early cerebral infarction associate with artery stenosis and the character of atherosclerosis plaques. The deterioration of cerebral and cervical vascular atherosclerotic stenosis may be associated with TCM matter of evil.