Effect Of Continuous Application Of Scopolamine And Anisodamine On Short-term Recurrence Of Intussusception In Children

Objective To investigate the effect that continuous application of different dosage of scopolamine andanisodamine on reduction of children intussusception after recent recurrence; To verify the intussusception vasospasm and to evaluate the effects of clinical application of different spasmolysis medicine for the treatment and prognosis of pediatric intussusception.Method 491 cases of intussusception in children between October 1, 2013 and October 30, 2014 were diagnosed and grouped in our hospital, treatment group and control group. Scopolamine treatment group was divided into 90 cases of high-dose group(group A), low-dose group, 90 cases(group B); Anisodamine treatment group was divided into 90 cases of high-dose group(group C), low-dose group, 90 cases(group D); antispasmodic drugs do two kinds of intussusception in children 90 cases in the control group(group E). Patients with intussusception were observed recurrence in the treatment process, recording the recovery time of intestinal function, recording the 48 hours serum CRP value of every children admitted to hospital. Recording respiratory, pulse, blood pressure values and comparing with the average value of normal children. This paper processes the gained data in a statistical way.Results The clinical manifestations of children with good matching of each group, there was no significant difference between groups(P>0.05). The treatment group of scopolamine recurrence in 6 cases, accounting for 3.3% of the group of patients, the treatment group of anisodamine recurrence in 20 cases, accounting for 11.1% of this group of cases, children with scopolamine treatment group was significantly lower than the treatment group of anisodamine in the rate of recurrence of intussusception(P = 0.004, P <0.05). A, B treated group of patients with intussusception recurrence rate lower than the control group, the difference was statistically significant(P=0.00, P<0.05, P=0.001, P<0.05). Compared with the control group, A、B group in children with faster recovery in the intestinal function, the difference was statistically significant(P<0.05). Compared with the control group, group C patients in intestinal function recovered rapidly, the difference was statistically significant(P<0.05). Scopolamine group before admission, serum CRP values elevated in 167/180 patients, 48 hours after admission to the normal values of serum CRP in 139 cases; Anisodamine group before admission, serum CRP values elevated in 155/180 patients, 48 hours after admission to the normal values of serum CRP in 110 cases; The control group before admission, serum CRP values elevated in 76/92 patients, 48 hours after after admission to the normal values of serum CRP in 33 cases. Compared with control group, the application of scopolamine group with serum CRP dropped to normal quickly, the difference was statistically significant(P < 0.05).Conclusion Continuous application of scopolamine and anisodamine in antispasmodic treatment has a great significance to preventing children intussusception from short-term recurrence in hospitalization. The spasmolysis effect with high and low dose of scopolamine is better than that of anisodamine, at the same time, the side effect of spasmolysis medicine is small,to the children with intussusception, it may play a positive role in the recovery of intestinal function.