Effect Of Patients With Shuganliqi,qingrehuayu Method To Evaluate The Treatment Of Post-stroke Depression And Effect On Serum Cytokine Levels

Objective: the aim of this study was to observe the Shuganliqi,qingrehuayu stasis in treatment of post-stroke depression(Post-stroke depression, PSD) in patients with clinical efficacy, and its influence on serum cytokines of IL-1, IL-6 and TNF-a level changes,preliminary study of Shuganliqi,qingrehuayu stasis in treatment of post-stroke depression(PSD) mechanism of patients.Method: 60 PSD patients selected met the study criteria were, according to visit order, using the method of random assignment into treatment group(Shuganliqi,qingrehuayu stasis method, combined with duloxetine treatment) and control group(duloxetine treatment) of the 30 cases, treatment for 8 weeks, Hamilton depression scale respectively in the treatment of treatment before and 2 week, 4 week treatment and after 8 weeks of treatment(HAMD), the score of neural function defect score(NIHSS), ability of daily life(ADL) and the self- made traditional C hinese medicine syndromes of post-stroke depression rating scale score. Comparison between the treatment group and the control group, the clinical efficacy evaluation of Shuganliqi,qingrehuayu stasis in treatment of post-stroke depression. And never in our hospital for the normal population of health examination in 30 cases were selected as the normal group, the determination of cytokine levels and treatment group, control group before and after treatment, comparison, discussion of Shuganliqi,qingrehuayu stasis mechanism.Results: reduced the treatment group and the control group after treatment HAMD score, NIHSS score, ADL score and TCM syndrome score than before treatment were, and the treatment group was superior to the control group, the difference was statistically significant(P < 0.01). Only HAMD score after 2 weeks of treatment, the treatment group than in the control group showed a significant decreasing trend, this advantage has been maintained until the eighth week, the difference was statistically significant(P < 0.01). After treatment for 4 weeks, 8 weeks after the NIHSS score, ADL score, treatment group and control group comparison between groups was statisticallysignificant(P < 0.01). Serum PSD in patients with IL-1, IL-6 and TNF-a level was increased compared with normal control group, the treatment group and the control group after treatment the serum IL-1, IL-6 and TNF-a levels were significantly reduced, and the treatment group effect is more obvious, the treatment group and the control group comparison between groups was statistically significant(P < 0.01).Conclusion: Shuganliqi,qingrehuayu method combined with antidepressant drugs than single use of antidepressant drugs in the treatment of PSD patients with rapid onset, short course of treatment, can significantly improve the score of HAMD and TCM syndrome score, also can promote the recovery of nerve functio n, reduce the single western medicine treatment of adverse reaction, high security, curative effect is better the. Shuganliqi,qingrehuayu method combined with duloxetine in the treatment of patients with PSD mechanism may be related to serum cytokines IL-1, IL-6 and TNF-a level changes related to.