| BACKGROUND:Primary liver cancer is a common digestive system malignant tumor, early onset hidden, by the time the diagnosis is often into the period, the inefficiency of operation. Now is given priority to with conventional minimally invasive interventional treatment as terminal-stage liver cancer treatment.Mainly the catheter with conventional selective target artery or the super selective inserted into the tumor blood supply, local chemotherapy and use of anti-cancer drugs into the right amount of embolic agents at the appropriate speed, make the target artery occlusion, ischemic necrosis in the tumor tissue. Embolization in the treatment of liver cancer with conventional play a very important role in the process, so choose the appropriate embolic agents is essential to the curative effect with conventional.OBJECTIVE:To observe sodium alginate microspheres and gelatin sponge embolism agent in the treatment of primary liver cancer with conventional curative effect comparison.METHODS:Primary liver cancer were randomly divided into two groups by using different embolic agents to 40 patients:KMG group (20 cases):embolization using sodium alginate microspheres, sponge group (20 cases):using gelfoam embolization. Selection criteria for new tumor patients, tumor size is less than 10 cm, the number of not more than three, liver function grade A or B, patients with distant metastasis. Observe two groups one month after the change of tumor size, the change of AFP levels and 3,6,12 month survival. Effective and quantity of iodine oil with the patient’s liver meritorious service is related to tumor size, focal range greater than 5 cm, liver function for class A,10 mg with iodine oil,30 mg, arsenic trioxide both mixed injection under C arm fluoroscopy. Less than 5 cm lesions or half liver function for class B or reduction. KMG embolism, namely first the microspheres into syringes, plus saline wash 3 times repeatedly, then add the contrast agent mixed with microspheres, uniform slow injection via catheter, according to the injection velocity of embolization agent and presence of reflux condition to determine the embolization agent, the dosage of prevent injection too fast lead to reflux. Again after embolization angiogram, according to the need can further injection of embolization agent until completely blood supply artery embolism. Need special pointed out that when sodium alginate microspheres injection must control the slow injection, the first evidence of reflux immediately stop injection, in case of ectopic embolism.Sponge embolism, the sponge must be cut into granular mixture contrast agents, injection process with KMG group.RESULTS:Two groups of patients with preoperative data no statistical significance (P> 0.05); KMG group 1 month after treatment in 16 cases (80%), tumor control group with 10 cases of tumor (50%); KMG before treatment group with 16 cases of AFP is higher than normal,1 month after treatment group KMG numerical fell by more than 30%(75%),12 cases with 5 to normal levels. AFP has 14 patients were higher than normal,7 cases after treatment numerical fell by more than 30% (50%),2 cases to normal levels. KMG and sponge group 3,6 months of survival rate are 90%,70% and 80%,90% respectively (P> 0.05),1 year survival rate are 50% and 50% respectively (P< 0.05).CONCLUSION:compared with gelatin sponge, sodium alginate microsphere embolization in the treatment of primary liver cancer with conventional forward effect is better. |
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