B-type Natriuretic Peptide And Platelet Parameters Change In Patients With Chronic Heart Failure

Objective The aim of this study is to observe the changes in patients with chronic heart failure by assaying plasma B-type natriuretic peptide concentration and platelet parameters in blood routine examination, and to assess the diagnosis value of BNP in patient with CHF by using ROC curve.Methods 353 patients with CHF in our department of cardiology and 40 patients with non-CHF were selected in this study. All patients underwent physical examination, electrocardiogram, blood sampling for examination of serum B-type natriuretic peptide and a complete blood count.Results There was no significant difference between CHF group and non-CHF group about gender, age, platelet counts (PLT), plateletocrit (PCT) and mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio (P-LCR) in CHF group were significantly higher than that of non-CHF group (P<0.001). Plasma BNP test results with the increase of NYMA graded gradually from low to high, which class â…  and class â…¡ there was no statistically significant difference (P>0.05).There was visible difference between class â…¡ and class â…¢, as well as class â…¢ and class â…£(P<0.0001). CHF group, the area under the ROC curve is 0.73(95% CI: 0.67-0.80). The sensitivity and specificity of BNP were 64%,85% respectively (cutoff: 68pg/ml).Conclusion Extent of plasma BNP in patients with CHF, PDW, P-LCR, MPV, blood platelet parameters, such as joint BNP testing as the CHF patients provide valuable reference for clinical diagnosis.