Clinical Observation Of Kang Ai Injection Plus Chemotherapy In The Advanced Non-small Cell Lung Cancer

Objective: This study through prospectie cohort study,evaluate the regimen,s clinical efficacy Kang Ai injection combined with western medicine chemotherapy and the effect of improving the quality of life,reducing the toxicity of chemothera py.This study provides clinical support forintegrative medicine in the treatment of a dvanced non-small cell lung cancer(NSCLC).Method: Patient collected from January 01, 2013 to December 31, 2014 in the xin jiang autonomous region hospital and xinjiang tumor hospital were diagnosed by of the histological and/or cytology pathology,with complete follow-up date of 54 pati ents with advanced non-small cell lung cancer.There are objective measureable lesio n.Patients were divided into Kangai injection in combination with chemotherapy gro up(treatment group)and simple chemotherapy group(control group).the treatment grou p at the same time add Kangai injection(Changbai Mountain pharmaceutical Limite d by Share Ltd)60m L,intravenous drip,1 times a day,the control group with chemo therapy alone,every 21 days for one cycle.After two cycles,the recent efficacy was evaluated according to RECIST 1.1criteria,before and after treatment of quality of life was evaluated according to the Karnofsky score and the weight changes,toxic reaction was evaluated according to NCICTC 3.0 version standard.The data for stati stical analysis obtained by SPSS 19.0,with P<0.05 for the difference has statistical significance.Results: Objective efficiency rate was 25.0% in the treatment group of the 54 pati ents,and the control group was 19.2%(P=0.856),disease control rate was 85.7% in t he treatment group,and the control group was 69.2%(P=0.260),there was no signific ant difference.After treatment,two groups,KPS score increase rates were 50.0%,15.4% respectively,with significant difference(P=0.016).Weight increase rates of the two groups after treatment were 46.4%,15.4%,with significant difference(P=0.031).In the treatment group,I~IV degree of leucopenia,thrombocytopenia and incidence of adv erse reactions such as nausea and vomiting,alopecia were 39.3%,28.6%,25.0%,and l ower than the control group(73.1%,61.5%,57.5%,respectively)(all P<0.05),there w ere significant differences.In the treatment group,I~IV degree of hemoglobin decrea se and the incidence of alopecia were 28.6%,42.9%,also lower than the control gro up(34.5%,69.2%,respectively)(P>0.05),but there was no significant difference.Conclusion: In patient with advanced non-small cell lung cancer chemotherapy,Ka ngai injection has obvious prevention and treatment effect for bone marrow inhibiti on and gastrointestinal reaction.It can reduce the side effects of chemotherapy,impr ove quality of life,improve the cellular immune function.Kangai injection can impr ove the efficacy of patients with lung cancer chemotherapy,has no obvious side ef fects,and has good security.It is a better choice for the comprehensive treatment o f advanced non-small cell lung cancer.