The Research With Domestic Violence In Patients With Alcohol Dependence Social Psychological Factors And GIuR-6 Gene Polymorphism

Objective:1.To investigate the association between glutamate receptor-6 (GIuR6/GRIK2)gene polymorphism and domestic violence in Xinjiang Han population on alcoholics.2.To investigate the association between glutamate receptor-6 (GIuR6/GRIK2)gene polymorphism and domestic violence in Xinjiang uighurs on alcoholics.3.To explore the social psychological factors in patients with alcohol dependence of family violence, and to provide a scientific basis for the psychological intervention in patients with alcohol dependence.Methods:l.People which will to accept the study on June 2,2011 to June 20,2013 hospitalized in Xinjiang mental health center, and drinking the people’s Hospital of Xinjiang Autonomous Region Department of clinical psychology and consistent with the CCMD-3 diagnosis standard of alcohol dependence in men of Han nationality, They fill in the domestic violence questionnaire with fasting blood the next day early morning, then Polymerasing chain reaction (PCR) polymorphism of GIuR-6 gene rs6922753 without violence, rs2227283 locus detection method of product direct sequencing of 42 cases of violence and Han population alcohol dependence and 72 cases of Han population patients with alcohol dependence.2.People which will to accept the study on June 2,2011 to June 20,2013 hospitalized in Xinjiang mental health center, and drinking the people’s Hospital of Xinjiang Autonomous Region Department of clinical psychology and consistent with the CCMD-3 diagnosis standard of alcohol dependence in men of Han nationality, They fill in the domestic violence questionnaire with fasting blood the next day early morning, then Polymerasing chain reaction (PCR) polymorphism of GIuR-6 gene rs6922753 without violence, rs2227283 locus detection method of product direct sequencing of 42 cases of violence and Uighurs alcohol dependence and 72 cases of Uygur patients with alcohol dependence.3.With A cross-sectional survey For willing to accept the study on June 2,2011 to June 20,2013 hospitalized in Xinjiang mental health center, and drinking the people’s Hospital of Xinjiang Autonomous Region Department of clinical psychology, consistent with the CCMD-3 diagnosis standard of male alcohol dependence, According to the family violence has no history into violence group (87 cases) and non violent group (84 cases). Using the questionnaire of family violence, Trait Coping Style Questionnaire (TCSQ), made the social support rating scale (SSRS) were investigated.Results:1.The frequence of allele and genotype of rs6922753 and rs2227283 polymorphisms in the domestic violence group were statistically different from those in the no domestic violence group(P<0.05).2.The frequence of allele and genotype of rs6922753 and rs2227283 polymorphisms in the domestic violence group were statistically different from those in the no domestic violence group(P<0.05), The allele frequencies of rs2227283 genotype and the difference is not statistically significant (P>0.05).3.Alcohol dependent patients group has lower age group than Non Violence violence, the difference was statistically significant (P<0.05).4.The difference was not statistically different (P>0.05),between alcohol dependence assault group and non violence in the education group.5.Alcohol dependence assault group and non violence group in the occupation violence group individual occupation are more than assault group, the difference was statistically significant (P<0.05).6. no violence group were significantly more than no violence group in divorce in the marriage violence group in alcohol dependence assault group, the difference was statistically significant (P<0.05).7.Alcohol dependence assault group and non violence in the aspects of income group in violence group overall incomes are belower than without violence group, the difference was statistically significant (P<0.05).8.Alcohol dependence assault group tends to violence to solve the family problems, and in the process of growing up with having the father beat family members were more than those in non violence group in the violence in the group, the difference was statistically significant (P<0.05).9.Alcohol dependence group violence in childhood who are members of the family maltreatment is significantly higher than that of non violence group, the difference was statistically significant (P<0.05).10.Alcohol dependence assault group holding the objective support score, subjective, utilization of support, social support score compared with the non violent group were no significant difference (P>0.05). Assault group to actively deal with the branch, negative coping with no violence group there was no difference in Statistics (P>0.05).Conclusion:1.GIuR-6 gene polymorphism may be associated with domestic violence in Xinjiang Han population on alcoholics.2.GIuR-6 gene polymorphism may be associated with domestic violence in Xinjiang uighurs on alcoholics.3.Alcohol dependence patients with adverse, assault group family relationship of low income, children contact with violent history period of patients with alcohol dependence take implementation of family violence easily.4.Patients relying on two groups of wine haveno special significance with the social support and coping style on family violence.