The Correlation Research Of HPV Subtype With Occurrence And Prognosis Of Cervical Lesions

Object:To investigate the correlation of high-risk human papilloma virus and varying degrees of cervical lesions and prognostic。Methods:Chose our hospital patients whose high-risk HPV (human papilloma virus) positive and pathological diagnosis of cervical lesions for patients with cervical lesions.After3-12months treatment of follow-up underwent HR-HPV, cytology.Results:(1) HR-HPV infection rates were:53.79%,61.9%,77.5%,61.9%for chronic cervicitis, CINI, CINII-CINIII and cervical cancer, the groups of lesions in group of HR-HPV infection rate X2test, difference was statistically significant (X2=38.752, P<0.05).(2) HPV16in detection rate of chronic cervicitis, CINI, CINII+CINIII and cervical cancer system are all in the first place, and the detection rate in different cervical lesions in the difference was statistically significant (P<0.05), HPV16affects the degree of cervical lesions, along with the increase of level of cervical lesions, HPV16detection rate also increase.15kinds of detection subtypes in different cervical lesion detection rate of the difference had statistical significance (P<0.05).(3) The highest detection rate five system in300patients were followed up are:HPV16,58,52,53,18; Detection rate of HPV16in cervical cancer reached62.5%;HPV16and HPV53in different cervical lesion detection rate difference were statistically significant (P<0.05);HPV16,18,33,39,52,53, and58in the same cervical lesions share difference were statistically significant (P<0.05);HPV16,58negative rate of different treatments have significant difference (P<0.05).HPV58negative rate between difference capacity levels were statistically significant (P<0.05),(4) A single high-risk HPV negative rate after different treatments were statistically significant (P<0.05), double and multiple HPV negative rate after different treatment have no statistically significant difference (P>0.05).Single HR-HPV between different cervical lesions negative rate was statistically significant difference(P<0.05), the negative rate in the chronic inflammation, CINI, CINII+CINIIII and cervical cancer were50.75%(67/132),62.96%(51/81) and78.12%(25/32), along with the raising of cervical lesion level, single high-risk HPV infection after treatment negative rate also will increase obviously.(5)HPV16negative rate:36.67%,62.07%,75%and72%after four treatment have statistically significant different(P<0.05), HPV39has no radical treatment, the other three treatments negative rate were respectively:0,71.43%,50%, the difference was statistically significant different(P<0.05), the total four treatments negative rate were respectively:43.65%,63.53%,69.39%,63.53%, have statistically significant different(P<0.05).Acount for that HPV negative rate associated with treatment. Only drug therapy compared with the other three treatments negative rate had statistically different (P<0.05).6.Three groups of35years old or less,36-50years old,and 50or more, the HPV negative rate were66.7%(26/39),58.9%(112/190),40.8%(29/71), the three statistically different (P<0.05), compared with58type HPV negative rate in all age group were statistically different (P<0.05).7different high-risk HPV negative rate in different groups in terms of follow-up time in cervical lesions and cervical cancer, diverse X2test comparison, the rate difference has statistical significance (P<0.05), four different kinds of treatment follow-up time each sample rate X2test comparison, difference has statistical significance (P<0.05), with the passage of time four treatment methods will make the turn rate increased.End up in the process of correlated, the degree of pain and uterine volume, ARSM no correlation between each other.Conclusion:1. High-risk type HPV infection is affects the occurrence and development of cervical lesions at all levels, along with the increase of cervical lesion level, the probability of high-risk HPV infection is higher.2.HPV16is the most common system of cervical lesions at all levels, especially in cervical cancer detection rate is highest, followed by HPV58.HPV16is along the increase of cervical lesion level with highter infective rate.Again confirm that HPV16cause cervical cancer. most easily3. HPV58capacity afact the prognosis of patients with cervical lesions before treating, and HPV16doesn’t depend on the capacity level, after treatment the high-risk HPV persistent infection predict cervical lesions or recurrence.4. Level of cervical lesions in HPV16only affect the negative rate of patients, the others of HPV negative rate difference in the different level of cervical lesions, so it is not sure whether the severity of cervical lesions turn influence factors of high risk HPV.5. Different treatment all can effectively remove high-risk HPV infection, cervical cancer radical negative rate is higher, this data shows that the effect of different surgical treatment is superior to the interferon treatment. HPV16in different treatments had the greatest influence on prognosis.6. The negative rate of a single HPV infection prognosis was obviously higher than the couple and multiple infection.Acount for a single subtype of clearance is significantly higher than many subtypes.7. This data shows that older patients, negative rate is lower, that age is also factors affecting the rate of turn.8. Each level of cervical lesions after different treatment negativet rate increased as time gose by,the negative rate is highest.Comprehensive view, the negative rate of cervical cancer radical surgery is the hightest, may be related to the scope of operation, to prevent the residual and recurrence of cervical lesions.9. Even if the patients after treatment can be overcast, but there is also a high-risk HPV may infection again, can also be repeated infection or infection with a new subtype.