The Effect Of Oxycodone Hydrochloride In Preemptive Analgesia Induced By Faure Marin And The Concentration Of NO And Substance P In Blood In Rat Pain Model

Objective： The changes of NO and substance P concentrations ofoxycodone hydrochloride applications to observe Faure Marin induced painmodel rats before stimulation analgesia and in blood, to investigate the effect ofpreemptive analgesia mechanism of oxycodone hydrochloride.Methods：32healthy adult Wistar rats, male and female, weighing250-300g, were randomly divided into4groups (n=8), normal control group(group A) intraperitoneal injection of0.9%Sodium Chloride Solution2mL;Faure Marin model group (group B) claw palm subcutaneous induced pain onthe right side of rats with microinjector5%Faure Marin100μL injection;oxycodone hydrochloride induced drug group (group C) to pain before, FaureMarin pain induced by intraperitoneal injection of oxycodone hydrochloride30min before0.2mg kg-1; Faure Marin pain induced by intraperitoneal injectionof30min before oxycodone hydrochloride0.2mg kg-1; oxycodonehydrochloride induced pain before and after drug group (D group),30min afterFaure Marin pain induced by intraperitoneal injection of oxycodonehydrochloride0.2mg kg-1. Induced pain after1,10,20,30,45,60,90minobservation of animal pain behavior change, with cumulative pain scoreevaluation of pain behavior.90min with chloral hydrate anesthetized rats after heart, blood3mL, NO and P determination of change of the substanceconcentration.Results：Blood samples of C, NO concentration in the D group comparedwith B group, the difference was statistically significant (P<0.01), between Cgroup and D group, the difference is statistically significant (P<0.05); substanceP concentrations of C, D group compared with B group, the difference wasstatistically significant (P<0.001), between C group and D group, the differencewas statistically significant (P<0.05).Conclusion： There is obvious analgesic effect of oxycodonehydrochloride in Faure Marin rat pain model induced by intraperitonealinjection of30min before and after formalin induced pain, and the analgesiceffect is associated with a lower concentration of NO and P substances in theblood. With the comparison of administration after30min, there is a moresignificant analgesia of administration before30min, which is a morepreemptive analgesia effect.