The Clinical Research Of Oxycodone Hydrochloride Injection For Analgesia After Gynecological Laparoscopic Operation

Objective: To explore the clinical effect of oxycodone hydrochloride injection for analgesia after gynecological laparoscopic.Method: Eighty patients undergoing elective gynecologic laparoscopic with general anesthesia, 20 to 50 years old, ASA Ⅰ~Ⅱ, were entered into this Institutional Review Board-approved. They were randomly divided into two grops(n=40): oxycodone hydrochloride injection group(group O) and fentanyl citrate injection group(group F). Five minutes before closure, oxycodone 10 mg was injected intravenously in group O and fentanyl 0.1mg in group F. After tracheal extubation, all patients were observed in PACU for one hour, VAS score and Ramsay sedation score 15 min, 30 min and 60 min after extubation were recorded, the adverse reactions such as respiratory depression were also recorded. Then assess the VAS pain score 2 hours, 4 hours, 8 hours, 12 hours and 24 hours after operation, when during rest or movement(cough, roll over or walking). Record the time when the VAS was more than or equal to 4 for the first time, and the number of paitients asking for additional analgesia, observe the adverse reactions such as PONV and itching in 24 hours. The time of anal exhaust were recorded and the satisfaction degree of analgesia with comfort score(BCS) were also evaluated.Results: There was no diffierence in age, body mass index, surgical time and the time of postoperative extubation in these two groups(P >0.05).The VAS pain scores and Ramsay sedation scores at 15 min, 30 min, 60 min after extubation were not statistically significant(P>0.05). No respiratory depression occurs in either group. The VAS pain scores in group O 2 hours, 4 hours and 8 hours after operation were significantly lower than those in the group F(P <0.05), but there was no statistically significant diffierence in VAS pain scores 12 hours to 24 hours after extubation. The time when the VAS more than or equal to 4 for the first time was much longer(P<0.05), and the number of cases asking for additional analgesia was much less in group O(P<0.05). The incidence of postoperative nausea and vomiting in group O was lower(P<0.05); The comfort scores of 24 hours after operation had no statistical significance in these two groups(P>0.05). Patients of group O got a higher degree of satisfaction(P<0.05).Conclusion: Oxycodone hydrochloride injection had exactly analgesic effect for laparoscopic gynecologic, which can effectively alleviate the early postoperative pain in minimally invasive surgery, the analgesic limitation had obvious pertinence. Compared with fentanyl, oxycodone hydrochloride had a significantly lower rate of adverse reactions.