The Clinical Systematic Review In Treatment Of Chronic Renal Failure By Strengthening Spleen And The Experimental Study In Affecting Rat Renal Function On The Model Of Chronic Renal Failure Induced By Adenine

Objectives: Throughing the clinical system review, in the basement of analyzing andsummaring the therapy clinical effects of strengthening the spleen and invigorating thekidney, combing modern technique in animal experiment, treat the rat model of chronicrenal failure induced by adenine with jianzhong lilao decoction. Discussing and verifyingthe mechanism of jianzhong lilao decoction in affectting rat renal function or not.Methods:(1)System evaluation method is used for1990-2013on the spleen andkidney method for treatment of chronic renal failure clinical literature analysis.Comprehensive quality assessment of included in the literature, to extract the completedata information. Then using Revman5.0meta analysis, come to the conclusion.(2)Adaptability to70male SD rats fed7days after weighing, tag, according to the weight andthe random number table divided into7groups. Using adenine lavage replicate the ratmodel with chronic renal failure, at the same time to the early intervention in the high andlow dose form jianzhong lilao decoction lavage. Partial executed, respectively, in themiddle of the experiment, end, rats and serum specimen collection, detection of BUN, SCrand so onResults:(1)Through the study12piece of clinical literature shows that meta analysis,with western medicine foundation treatment, joint of spleen and kidney in traditional Chinese medicine treatment can improve the clinical curative effect of patients withchronic renal failure. Effectively reduce the level of the Scr, to reduce the effect of theBUN is also more prominent. The effect of spleen and kidney in traditional Chinesemedicine (TCM) on chronic renal failure is better than that of compound-alpha keto acid,Coated Aldehyde Oxystarch such as western medicine. In improving24h urine proteinquantitative meta analysis shows that spleen and kidney in Chinese medicine curativeeffect is better. Regardless of pure Chinese medicine or Chinese medicine combining withthe foundation treatment,12articles according to test security is higher, less adversereaction.(2) Animal experiments found that jianzhong lilao decoction has reliable curativeeffect in reducing chronic renal failure rats BUN and SCr (p<0.05), suggesting jianzhonglilao decoction can enhance the recovery of chronic renal failure rat kidney function.Conclusion: System evaluation through literature analysis indicates that the curativeeffect of treatment of chronic renal failure by the method of strengthening spleen andinvigorating kidney is reliable and safe. Experimental proof chienchung Richard lowe soupBUN SCr, effectively reduce the chronic renal failure rats delay renal failure in rats.Therefore we conclude: Strengthening the Spleen has good therapeutic effect on chronicrenal failure, Jianzhong Lilao Decoction can promote the renal function recovery, slowprogress in renal failure.