Affect Of Glycemic Variability In Normal, Overweight, Obesity People By High Fat Diet

Objective:1. Analysis of the effect of high-fat diet for glycemic variability in normal, overweight, obesity people.2. Analysis of the characteristics of glycemic variability in normal, overweight, obesity people by high-fat diet.3. Discuss the effect on blood sugar by high-fat diet.Methods:Select36cases without a family history of diabetes and diabetic,and eliminate affect glucose metabolism, disease for example hyperthyroidism, liver disease, high blood sugar, endocrine tumors caused by high blood sugar, hyperglycemia and drugs.According to the BMI, devide into3groups,normal group18.5<BMI<24, overweight group24<BMI<28, and robesity group28<BMI. Collected clinical data and general information, and sign the informed consent. Give each group first3day normal diet. After1week of washout period given a high-fat diet for three days.CGMS equipment used for calibration, every night to download the data recorded by CGMS in blood glucouse. Use SPSS17.0software to process data. Use EasyGV software to calculate glycemic variability, including SMBG, SDBG, M-value, MAGE, J-index, MODD, CONGA, and GRADE.Results:1.In normol group, high-fat diet has no statistically significant effect on glycemic variability, includeing the MAGE, J index, MODD, M value, CONGA, GRADE.(P>0.05).2. The data of this study showed that in overweight people, dietary fat content increased from30%to50%has effect on glycemic variability.(P <0.05), the specific performance in the MAGE, MODD, M value and CONGA. It indicates that increasing the proportion of dietary lipids for overweight people have an impact on glycemic variability.3. The data of this study showed that in obese group, dietary fat content increased from30%to50%has effect on glycemic variability.(P<0.05), the specific performance in the MAGE, MODD, M value and CONGA. It indicates that increasing the proportion of dietary lipids for obese people have an impact on glycemic variability.Conclusion:The change of the proportion of fat in diet has no effect on normal people’s glycemic variability. But for overweight and obese people this change had a greater effect on the glycemic variability.