Clinical Research And Analysis Of Rheumatology In Patients With Fever Of Unknown Origin

Objective:In order to improve the accuracy of diagnosis of FUO, investigate the regularity,summarize experience, we make the report on clinical analysis for192cases of fever ofunknown through the proportion and their characteristics, and analysis the FUO with thesame or similar clinical symptoms or signs of FUO of common diseases to summary theexperience and therapeutic experience and to guide clinical diagnosis and treatment.Method:We have chosen192cases of FUO in patients in the Department of Rheumatology inThe Center Hospital of Taian from January2011to December2013. The patients’information of clinical features, etiology, age, gender, duration of fever, inflammatorymakers, diagnostic methods ect. were collected and analyzed. Chi-squared test wasperformed via the SPSS13.0system.Result:169cases were confirmed among the192hospitalized patients with FUO. The maincauses of FUO in this study are: connective tissue diseases and vasculitis（61.46%）,infectious diseases（22.40%）,malignant tumor（2.08%）,other diseases（2.08%）.The unidentified cases in this study accounted for11.98%.The diseases thatcaused FUO in this study contained systemic lupus erythematosus, adult Still’s disease,polymyalgia rheumatica, Sjogren’s syndrome, pulmonary bacterial infection, EB virusinfection, tuberculosis, urinary tract infections ect. Among the169diagnosed patients,women accounted a higher proportion than men, especialy in the connective tissue diseasesgroup. By classification of age, older age group （41-60）accounted for the largestproportion in FUO patients. In each age group connective tissue disease and vasculitisdisease accounted for the largest proportion. By classification of fever duration, infectious diseases composed the highest proportion in≤1month fever duration group, and thelonger the duration, the less the likelihood of infectious diseases. By classification oflaboratory indicators in certain disease, each disease group had increased level of RBC,ESR, CRP, and SF. But the level of SF increased significantly in the connective tissuedisease and vasculitis disease in contrast with other disease groups.Conclusion and Significance:Most FUO patients can eventually be diagnosed after detailed medical history, strictphysical examination, specialized laboratory tests and diagnostic treatment. In our study,connective tissue disease and vasculitis disease is the major reason that can lead FUO,while infectious disease is in the second place. While connective tissue diseases andvasculitis are most common reasons for young women patients, elderly patients with FUOshould take malignant tumor as the first concern. The clinical characteristics of FUO casesare summarized in this study to improve the diagnostic accuracy of FUO and to provide arational strategy to guide clinical practice.