Research On Retinal Characteristics Of Qi And Yin Deficiency Diabetic Retinopathy Patients

Objective:Research on fundus changes of non-proliferative diabetic retinopathy(NPDR) patients, which the syndrome differentiation in traditional Chinese medicine(TCM) is qi and yin deficiency. Explore the relevance tendency between the quantitative fundus changes and syndrome tendency.Methods:A multi-center clinical trial was conducted, Type2NPDR and Qi-Yin deficiency patients were included and grouped into Qi deficiency tendency, Yin deficiency tendency and subtype of qi and yin deficiency (without tendency). General information and TCM symptoms scale were recorded, fundus photographs using the Modified7-Standard Field Digital Color Fundus Photography(7M-D) developed by Fundus Photograph Reading Center(FPRC) of University of Wisconsin. The number of microaneurysm, area of fundus hemorrhage and hard exudates were extracted by image software according to the pixel and precision coefficients of the fudus camera. Datum were analyzed using statistical software.Result:①Of124included patients, disc area extracted from the color fudus photographs of the same patient taken by different photographers at different time was stale, and of good reproducibility.②NPDR Qi-Yin deficiency patients’syndrome tendency and the couse of DM were significant statistically (P<0.01).③Comparing the three groups, there was no statistically significance between each subtype groups (P>0.05); for microaneurysm, it might be statistically significant (P=0.05); but for hemorrhage area, it was statistically significant (P<0.05).④Between comparing two of groups, quantity of microaneurysm between Qi deficiency tendency and Yin deficiency tendency was statistically significant (P<0.05); The area of hemorrhage between Qi deficiency tendency and Yin deficiency tendency, yin deficiency tendency, without qi or yin tendency was statistically significant (P<0.05)Conclusion:①According to the fundus photographs, disc area extracted from the color fudus photographs of the same patient taken by different photographers at different time was not statistically significant (P>0.05);②NPDR Qi-Yin deficiency patients’qi deficiency tendency, yin deficiency tendency, without qi or yin tendency and the couse of DM was significant related.③Quantity of microaneurysm of NPDR Qi-Yin deficiency patients between Qi deficiency tendency and Yin deficiency tendency was significant related.④The area of hemorrhage between Qi deficiency tendency and Yin deficiency tendency, yin deficiency tendency, without qi or yin tendency was statistically related.