Clinical Applications Of Fractional Flow Reserve In The Percutaneous Coronary Intervention In Patients With Coronary Borderline Lesion

BackgroundAs an important index for assessing the functional information ofcoronary artery, Fractional flow reserve(FFR) has been widely used in theevaluation of coronary artery lesions.It’s very important to settling on thetherapy in the way of assessing the functional information,especially forthe coronary borderline lesion.If only depending on the the result ofCAG,the therapy is too conservative or too radical,which will bothincrease the risk of the related diseases.We establish this subject for theassessment of FFR in the coronary artery lesions.In addition,the researchis for verifying the value of clinical application of fractional flow reserve.ObjectiveTo study the value of clinical application of fractional flowreserve(FFR) for guiding percutaneous coronary intervention (PCI) inpatients with borderline lesion of coronary heart disease(CHD).Methods40patients with coronary heart disease adminitted to Second Hospital of Jilin University from June2013to June2014were enrolled inthe study,whose extents of coronary stenosis verified by CAG wereborderline lesion(50-70%).They were divided into two groupsrandomly,one was FFR guiding group,the patients in this Groupunderwent FFR measurements in each diseased coronary artery, and drugeluting stent（sDES）were placed in indicated lesions only if the FFR was0.08or less,the other group was no FFR guiding group, the doctorschoose the therapies for the patients depends on these clinical data,implanting DES or not.The number of stents were compared betweentwo groups.The rates of recurring angina and major adverse cardiacevents(MACE) were recorded in6months.ResultsThe number of stents were significantly different between twogroups(0.16士0.37vs0.33士0.48，P<0.05)；There were significantdifferences in6months rate of recurring angina (5%vs10%，P<0.05)，but there were no significant differences in6months rate of MACEbetween two groups（5%vs14%，P＞0.05）.Conclusion1.On the base of the measurement of FFR in intermediate coronaryheart disease undergoing PCI can reduce the number of stents.2.On the base of the measurement of FFR in intermediate coronaryheart disease undergoing PCI does not increase the rate of MACE, it can reduce the rate0f angina.FFR could be the importent basis to decidewhether intermediate coronary heart disease should accept PCI.